Progress in Structure Based Drug Design for G Protein-Coupled Receptors

被引：157

作者：

Congreve, Miles ^{[1
]}

Langmead, Christopher J. ^{[1
]}

Mason, Jonathan S. ^{[1
]}

Marshall, Fiona H. ^{[1
]}

机构：

[1] Heptares Therapeut Ltd, Welwyn Garden City AL7 3AX, Herts, England

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 54卷 / 13期

关键词：

SITE-DIRECTED MUTAGENESIS; X-RAY-STRUCTURE; CRYSTAL-STRUCTURE; BINDING-SITE; ALLOSTERIC MODULATION; PHARMACOLOGICAL CHARACTERIZATION; BETA(2)-ADRENERGIC RECEPTOR; ADENOSINE RECEPTORS; IN-SILICO; MOLECULAR RECOGNITION;

D O I：

10.1021/jm200371q

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：4283 / 4311

页数：29

共 185 条

[1] Kinase-targeted libraries: The design and synthesis of novel, potent, and selective kinase inhibitors [J].

Akritopoulou-Zanze, Irini ;

Hajduk, Philip J. .

DRUG DISCOVERY TODAY, 2009, 14 (5-6) :291-297

[2] An integrated approach to fragment-based lead generation: Philosophy, strategy and case studies from AstraZeneca's drug discovery programmes [J].

Albert, Jeffrey S. ;

Blomberg, Niklas ;

Breeze, Alexander L. ;

Brown, Alastair J. H. ;

Burrows, Jeremy N. ;

Edwards, Philip D. ;

Folmer, Rutger H. A. ;

Geschwindner, Stefan ;

Griffen, Ed J. ;

Kenny, Peter W. ;

Nowak, Thorsten ;

Olsson, Lise-Lotte ;

Sanganee, Hitesh ;

Shapiro, Adam B. .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2007, 7 (16) :1600-1629

[3] From purified GPCRs to drug discovery: the promise of protein-based methodologies [J].

Alkhalfioui, Fatima ;

Magnin, Thierry ;

Wagner, Renaud .

CURRENT OPINION IN PHARMACOLOGY, 2009, 9 (05) :629-635

[4] 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors [J].

Allegretti, M ;

Bertini, R ;

Cesta, MC ;

Bizzarri, C ;

Di Bitondo, R ;

Di Cioccio, V ;

Galliera, E ;

Berdini, V ;

Topai, A ;

Zampella, G ;

Russo, V ;

Di Bello, N ;

Nano, G ;

Nicolini, L ;

Locati, M ;

Fantucci, P ;

Florio, S ;

Colotta, F .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (13) :4312-4331

[5] An intracellular allosteric site for a specific class of antagonists of the CC chemokine G protein-coupled receptors CCR4 and CCR5 [J].

Andrews, Glen ;

Jones, Carolyn ;

Wreggett, Keith A. .

MOLECULAR PHARMACOLOGY, 2008, 73 (03) :855-867

[6] CB1 cannabinoid receptor antagonists for treatment of obesity and prevention of comorbid metabolic disorders [J].

Antel, Jochen ;

Gregory, Peter C. ;

Nordheim, Ulrich .

JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (14) :4008-4016

[7]

Ballesteros J. A., 1995, Neuroscience Methods, V25, P366, DOI [10.1016/S1043-9471(05)80049-7, DOI 10.1016/S1043-9471(05)80049-7, DOI 10.1016/S1043-9471]

[8] A refined agonist pharmacophore for protease activated receptor 2 [J].

Barry, Grant D. ;

Suen, Jacky Y. ;

Low, Heng Boon ;

Pfeiffer, Bernhard ;

Flanagan, Bernadine ;

Halili, Maria ;

Le, Giang T. ;

Fairlie, David P. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (20) :5552-5557

[9]

Barton N. P, 2007, COMPR MED CHEM 2, V4, P669

[10] Drug Design for G-Protein-Coupled Receptors by a Ligand-Based NMR Method [J].

Bartoschek, Stefan ;

Klabunde, Thomas ;

Defossa, Elisabeth ;

Dietrich, Viktoria ;

Stengelin, Siegfried ;

Griesinger, Christian ;

Carlomagno, Teresa ;

Focken, Ingo ;

Wendt, K. Ulrich .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (08) :1426-1429

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