SNC 80 and related δ opioid agonists

被引：20

作者：

Calderon, SN

Coop, A

机构：

[1] US FDA, CDER, Rockville, MD 20857 USA

[2] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA

来源：

CURRENT PHARMACEUTICAL DESIGN | 2004年 / 10卷 / 07期

关键词：

D O I：

10.2174/1381612043453054

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The discovery of the selective delta (delta) opioid agonists SNC 80 and BW373U86, which possess a diarylmethylpiperazine structure unique among opioids, was a major advance in the field of delta-opioid ligands. Much research has been performed to uncover the structure-activity relationships (SAR) of this class of ligands and also to compare the diarylmethylpiperazines with the traditional morphinan-based delta opioids. This review focuses on the development of the SAR of this unique series of ligands, and discusses questions which remain unanswered.

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页码：733 / 742

页数：10

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