Cooperation between Wnt and Notch signalling in human breast cancer

被引：30

作者：

Collu, Giovanna M. ^{[1
]}

Brennan, Keith ^{[1
]}

机构：

[1] Univ Manchester, Fac Life Sci, Wellcome Trust Ctr Cell Matrix Res, Manchester M13 9PT, Lancs, England

来源：

BREAST CANCER RESEARCH | 2007年 / 9卷 / 03期

关键词：

D O I：

10.1186/bcr1671

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Wnt and Notch signalling pathways play major roles in mammary gland development and tumourigenesis. During development, these pathways have opposing effects. However, in a recent paper Ayyanan and coworkers show that expression of Wnt1 is sufficient to transform primary human mammary epithelial cells, and that this is in part due to activation of the Notch pathway. This indicates that during tumourigenesis the two pathways cooperate. Here we ask why activation of Wnt signalling alone is sufficient to cause transformation; whether there is evidence for inhibitory crosstalk between the pathways during tumourigenesis; and whether cooperation between these pathways occurs in other forms of cancer.

引用

收藏

页数：3

相关论文

共 27 条

[21] Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation [J].

Timmerman, LA ;

Grego-Bessa, J ;

Raya, A ;

Bertrán, E ;

Pérez-Pomares, JM ;

Díez, J ;

Aranda, S ;

Palomo, S ;

McCormick, F ;

Izpisúa-Belmonte, JC ;

de la Pompa, JL .

GENES & DEVELOPMENT, 2004, 18 (01) :99-115

[22] Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion [J].

Uyttendaele, H ;

Soriano, JV ;

Montesano, R ;

Kitajewski, J .

DEVELOPMENTAL BIOLOGY, 1998, 196 (02) :204-217

[23] The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells [J].

van de Wetering, M ;

Sancho, E ;

Verweij, C ;

de Lau, W ;

Oving, I ;

Hurlstone, A ;

van der Horn, K ;

Batlle, E ;

Coudreuse, D ;

Haramis, AP ;

Tion-Pon-Fong, M ;

Moerer, P ;

van den Born, M ;

Soete, G ;

Pals, S ;

Eilers, M ;

Medema, R ;

Clevers, H .

CELL, 2002, 111 (02) :241-250

[24] Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells [J].

van Es, JH ;

van Gijn, ME ;

Riccio, O ;

van den Born, M ;

Vooijs, M ;

Begthel, H ;

Cozijnsen, M ;

Robine, S ;

Winton, DJ ;

Radtke, F ;

Clevers, H .

NATURE, 2005, 435 (7044) :959-963

[25] Notch and Wnt signaling in T-lymphocyte development and acute lymphoblastic leukemia [J].

Weerkamp, F. ;

van Dongen, J. J. M. ;

Staal, F. J. T. .

LEUKEMIA, 2006, 20 (07) :1197-1205

[26] c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma [J].

Weng, Andrew P. ;

Millholland, John M. ;

Yashiro-Ohtani, Yumi ;

Arcangeli, Marie Laure ;

Lau, Arthur ;

Wai, Carol ;

del Bianco, Cristina ;

Rodriguez, Carlos G. ;

Sai, Hong ;

Tobias, John ;

Li, Yueming ;

Wolfe, Michael S. ;

Shachaf, Cathy ;

Felsher, Dean ;

Blacklow, Stephen C. ;

Pear, Warren S. ;

Aster, Jon C. .

GENES & DEVELOPMENT, 2006, 20 (15) :2096-2109

[27] Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma [J].

Wu, WS ;

Heinrichs, S ;

Xu, D ;

Garrison, SP ;

Zambetti, GP ;

Adams, JM ;

Look, AT .

CELL, 2005, 123 (04) :641-653