Transcriptional and functional profiles of voltage-gated Na+ channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain

被引：88

作者：

Berta, Temugin ^{[1
,2
,3
]}

Poirot, Olivier ^{[4
]}

Pertin, Marie ^{[1
,2
,3
]}

Ji, Ru-Rong ^{[5
,6
]}

Kellenberger, Stephan ^{[4
]}

Decosterd, Isabelle ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Ctr, Dept Anesthesiol, Pain Res Unit, CH-1011 Lausanne, Switzerland

[2] Univ Lausanne, CH-1011 Lausanne, Switzerland

[3] Univ Lausanne, Fac Biol & Med, Dept Cell Biol & Morphol, CH-1005 Lausanne, Switzerland

[4] Univ Lausanne, Fac Biol & Med, Dept Pharmacol & Toxicol, CH-1005 Lausanne, Switzerland

[5] Brigham & Womens Hosp, Dept Anesthesiol, Pain Res Unit, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2008年 / 37卷 / 02期

关键词：

D O I：

10.1016/j.mcn.2007.09.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Changes in expression and, function of voltage-gated sodium channels (VGSC) in dorsal root ganglion (DRG) neurons may play a major role in the genesis of peripheral hyperexcitability that occurs in neuropathic pain. We present here the first description of changes induced by spared nerve injury (SNI) to Na(v)1 mRNA levels and tetrodotoxin-sensitive and -resistant (TTX-S/TTX-R) Na+ currents in injured and adjacent non-injured small DRG neurons. VGSC transcripts were down-regulated in injured neurons except for Na(v)1.3, which increased, while they were either unchanged or increased in non-injured neurons. TTX-R current densities were reduced in injured neurons and the voltage dependence of steady-state inactivation for TTX-R was positively shifted in injured and non-injured neurons. TTX-S current densities were not affected by SNI, while the rate of recovery from inactivation was accelerated in injured neurons. Our results describe altered neuronal electrogenesis following SNI that is likely induced by a complex regulation of VGSCs. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：196 / 208

页数：13

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