MicroRNAs: a developing story

被引：255

作者：

Pasquinelli, AE ^{[1
]}

Hunter, S ^{[1
]}

Bracht, J ^{[1
]}

机构：

[1] Univ Calif San Diego, Mol Biol Sect, Div Biol 0349, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2005年 / 15卷 / 02期

关键词：

D O I：

10.1016/j.gde.2005.01.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Considering the intense genetic efforts applied to understanding development, it is surprising that a relatively large class of regulatory genes has newly surfaced. The first microRNA gene and its developmental role were described more than ten years ago, but only recently have we fully appreciated the broad and abundant presence of such genes. MicroRNAs are similar to 22 nucleotide RNAs that use antisense complementarity to inhibit expression of specific mRNAs. Recent studies of restricted expression patterns and functional roles have implicated specific microRNAs in complex genetic pathways regulating embryogenesis, hematopoiesis, neuronal differentiation and Hox-mediated development.

引用

页码：200 / 205

页数：6

共 46 条

[1] Regulation of flowering time and floral organ identity by a microRNA and its APETALA2-like target genes [J].

Aukerman, MJ ;

Sakai, H .

PLANT CELL, 2003, 15 (11) :2730-2741

[2] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[3] AGO1 defines a novel locus of Arabidopsis controlling leaf development [J].

Bohmert, K ;

Camus, I ;

Bellini, C ;

Bouchez, D ;

Caboche, M ;

Benning, C .

EMBO JOURNAL, 1998, 17 (01) :170-180

[4] Trans-splicing and polyadenylation of let-7 microRNA primary transcripts [J].

Bracht, J ;

Hunter, S ;

Eachus, R ;

Weeks, P ;

Pasquinelli, AE .

RNA, 2004, 10 (10) :1586-1594

[5] MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode [J].

Chang, S ;

Johnston, RJ ;

Frokjær-Jensen, C ;

Lockery, S ;

Hobert, O .

NATURE, 2004, 430 (7001) :785-789

[6] MicroRNAs modulate hematopoietic lineage differentiation [J].

Chen, CZ ;

Li, L ;

Lodish, HF ;

Bartel, DP .

SCIENCE, 2004, 303 (5654) :83-86

[7] A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development [J].

Chen, XM .

SCIENCE, 2004, 303 (5666) :2022-2025

[8] Numerous microRNPs in neuronal cells containing novel microRNAs [J].

Dostie, J ;

Mourelatos, Z ;

Yang, M ;

Sharma, A ;

Dreyfuss, G .

RNA, 2003, 9 (02) :180-186

[9] MicroRNA regulation of gene expression in plants [J].

Dugas, DV ;

Bartel, B .

CURRENT OPINION IN PLANT BIOLOGY, 2004, 7 (05) :512-520

[10] Dicer is essential for formation of the heterochromatin structure in vertebrate cells [J].

Fukagawa, T ;

Nogami, M ;

Yoshikawa, M ;

Ikeno, M ;

Okazaki, T ;

Takami, Y ;

Nakayama, T ;

Oshimura, M .

NATURE CELL BIOLOGY, 2004, 6 (08) :784-791

← 1 2 3 4 5 →