Marine-derived biological macromolecule-based biomaterials for wound healing and skin tissue regeneration

被引：116

作者：

Chandika, Pathum ^{[1
,2
]}

Ko, Seok-Chun ^{[3
]}

Jung, Won-Kyo ^{[1
,2
]}

机构：

[1] Pukyong Natl Univ, Dept Biomed Engn, Busan 608737, South Korea

[2] Pukyong Natl Univ, Ctr Marine Integrated Biomed Technol Plus BK21, Busan 608737, South Korea

[3] Pukyong Natl Univ, Inst Marine Biotechnol, Busan 608737, South Korea

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2015年 / 77卷

基金：

新加坡国家研究基金会;

关键词：

Biological macromolecules; Marine organisms; Wound healing; Skin tissue engineering; MYTILUS-GALLOPROVINCIALIS L; POLYUNSATURATED FATTY-ACIDS; HYALURONIC-ACID; OXIDIZED ALGINATE; CROSS-LINKING; COLLAGEN SCAFFOLDS; POROUS SCAFFOLDS; ARTIFICIAL SKIN; RAPANA-VENOSA; SEA-CUCUMBER;

D O I：

10.1016/j.ijbiomac.2015.02.050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Wound healing is a complex biological process that depends on the wound condition, the patient's health, and the physicochemical support given through external materials. The development of bioactive molecules and engineered tissue substitutes to provide physiochemical support to enhance the wound healing process plays a key role in advancing wound-care management. Thus, identification of ideal molecules in wound treatment is still in progress. The discovery of natural products that contain ideal molecules for skin tissue regeneration has been greatly advanced by exploration of the marine bioenvironment. Consequently, tremendously diverse marine organisms have become a great source of numerous biological macromolecules that can be used to develop tissue-engineered substitutes with wound healing properties. This review summarizes the wound healing process, the properties of macromolecules from marine organisms, and the involvement of these molecules in skin tissue regeneration applications. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：24 / 35

页数：12

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