ATP-dependent chromatin remodeling complexes and their role in nuclear receptor-dependent transcription in vivo

被引:23
作者
Aoyagi, S [1 ]
Trotter, KW [1 ]
Archer, TK [1 ]
机构
[1] NIEHS, Chromatin & Gene Express Sect, Mol Carcinogenesis Lab, NIH, Res Triangle Pk, NC 27709 USA
关键词
D O I
10.1016/S0083-6729(05)70009-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Nuclear receptors (NRs) are ligand-dependent transcription factors that mediate transcription of target genes in chromatin. Modulation of chromatin structure plays an important part in the NR-mediated transcription process. ATP-dependent chromatin remodeling complexes have been shown to be intimately involved in NR-mediated transcription. In this review, we examine the role of chromatin remodeling complexes in facilitating the recruitment of coregulators and basal transcription factors. In addition, the role of subunit specificity within the chromatin remodeling complexes, the complexes' influence on remodeling activity, and complexes' recruitment to the NR-responsive promoters are discussed. (c) 2005 Elsevier Inc.
引用
收藏
页码:281 / 307
页数:27
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