Yeast as a model to study mitochondrial mechanisms in ageing

被引：41

作者：

Barros, Mario H. ^{[1
]}

da Cunha, Fernanda M. ^{[2
]}

Oliveira, Graciele A. ^{[2
]}

Tahara, Erich B. ^{[2
]}

Kowaltowski, Alicia J. ^{[2
]}

机构：

[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, BR-05508 Sao Paulo, Brazil

[2] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508 Sao Paulo, Brazil

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2010年 / 131卷 / 7-8期

关键词：

Energy metabolism; Reactive oxygen species; Calorie restriction; SIR; TOR; NAD; CHRONOLOGICAL LIFE-SPAN; CALORIE RESTRICTION EXTENDS; ELECTRON-TRANSPORT CHAIN; DEFICIENT SACCHAROMYCES-CEREVISIAE; MANGANESE-SUPEROXIDE DISMUTASE; OXIDATIVELY DAMAGED PROTEINS; SMALL-MOLECULE ACTIVATORS; OXYGEN SPECIES PRODUCTION; STRESS RESISTANCE; GENE-EXPRESSION;

D O I：

10.1016/j.mad.2010.04.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Despite the fact that ageing necessarily displays unique aspects in a single-cell organism, yeast, in particular Saccharomyces cerevisiae, are useful as model organisms to study ageing. Here we review mitochondrial characteristics involved in yeast longevity, including biogenesis, autophagy, respiration and oxidative phosphorylation, nutrient sensing, mitochondria-nuclear signaling, redox state and mitochondrial DNA integrity. Altogether, the yeast model unearths a rich and complex network involving many mitochondrial functions in ageing, and uncovers physiological and genetic mechanisms capable of extending lifespan in this model which may be shared with more complex organisms. (c) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：494 / 502

页数：9

共 185 条

[1] Function, structure, and biogenesis of mitochondrial ATP synthase [J].

Ackerman, SH ;

Tzagoloff, A .

PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 80, 2005, 80 :95-133

[2] Dietary activators of Sirt1 [J].

Allard, Joanne S. ;

Perez, Evelyn ;

Zou, Sige ;

de Cabo, Rafael .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2009, 299 (01) :58-63

[3] Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae [J].

Alvers, Ashley L. ;

Fishwick, Laura K. ;

Wood, Michael S. ;

Hu, Doreen ;

Chung, Hye S. ;

Dunn, William A., Jr. ;

Aris, John P. .

AGING CELL, 2009, 8 (04) :353-369

[4] A novel role of Mgm1p, a dynamin-related GTPase, in ATP synthase assembly and cristae formation/maintenance [J].

Amutha, B ;

Gordon, DM ;

Gu, YJ ;

Pain, D .

BIOCHEMICAL JOURNAL, 2004, 381 :19-23

[5] Yeast life-span extension by calorie restriction is independent of NAD fluctuation [J].

Anderson, RM ;

Latorre-Esteves, M ;

Neves, AR ;

Lavu, S ;

Medvedik, O ;

Taylor, C ;

Howitz, KT ;

Santos, H ;

Sinclair, DA .

SCIENCE, 2003, 302 (5653) :2124-2126

[6] Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae [J].

Anderson, RM ;

Bitterman, KJ ;

Wood, JG ;

Medvedik, O ;

Sinclair, DA .

NATURE, 2003, 423 (6936) :181-185

[7] Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels [J].

Anderson, RM ;

Bitterman, KJ ;

Wood, JG ;

Medvedik, O ;

Cohen, H ;

Lin, SS ;

Manchester, JK ;

Gordon, JI ;

Sinclair, DA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (21) :18881-18890

[8] RAS GENES [J].

BARBACID, M .

ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :779-827

[9] Aging defined by a chronologic-replicative protein network in Saccharomyces cerevisiae: An interactome analysis [J].

Barea, Fernanda ;

Bonatto, Diego .

MECHANISMS OF AGEING AND DEVELOPMENT, 2009, 130 (07) :444-460

[10] A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice [J].

Barger, Jamie L. ;

Kayo, Tsuyoshi ;

Vann, James M. ;

Arias, Edward B. ;

Wang, Jelai ;

Hacker, Timothy A. ;

Wang, Ying ;

Raederstorff, Daniel ;

Morrow, Jason D. ;

Leeuwenburgh, Christiaan ;

Allison, David B. ;

Saupe, Kurt W. ;

Cartee, Gregory D. ;

Weindruch, Richard ;

Prolla, Tomas A. .

PLOS ONE, 2008, 3 (06)

← 1 2 3 4 5 6 7 8 9 10 →