Enantioselective synthesis of 2-substituted-N-Boc-Δ-4,5-piperidines

被引：29

作者：

Agami, C ^{[1
]}

Couty, F ^{[1
]}

Evano, G ^{[1
]}

机构：

[1] Univ Paris 06, CNRS, UMR 7611, Lab Synth Asymetr, F-75005 Paris, France

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 23期

关键词：

D O I：

10.1016/S0957-4166(00)00462-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The title compounds were prepared through a synthetic sequence involving: (i) a reaction of the condensation product between an enantiopure beta -amino alcohol and an aldehyde with allylmagnesium chloride; (ii) an N-allylation of the resulting secondary amine; (iii) a chemoselective cleavage of the beta -amino alcohol residue; and (iv) a protection of the secondary amine followed by a ring closing metathesis. The advantageous use of (1R,2S)-norephedrine was demonstrated in these syntheses. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：4639 / 4643

页数：5

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