Carbohydrate analysis by desorption electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry

被引：30

作者：

Bereman, Michael S. ^{[1
]}

Williams, Taufika Islam ^{[1
]}

Muddiman, David C. ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem, WM Keck FT ICR Mass Spectrometry Lab, Raleigh, NC 27695 USA

来源：

ANALYTICAL CHEMISTRY | 2007年 / 79卷 / 22期

关键词：

D O I：

10.1021/ac0713858

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学]; 081704 [应用化学];

摘要：

We report the use of desorption electrospray ionization hybrid Fourier transform ion cyclotron resonance mass spectrometry (DESI-FT-ICR-MS) for the analysis of carbohydrates. Spectra of neat carbohydrates are presented along with their mass measurement accuracies and limits of detection. Furthermore, a comparison is made between the analyses of O-linked glycans from mucin by DESI-FT-ICR-MS and matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry. Finally, glycans from mucin are identified by using the high mass measurement accuracy and tandem MS capabilities afforded by the hybrid FT-ICR-MS platform.

引用

收藏

页码：8812 / 8815

页数：4

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