Direct Analysis of Biological Tissue by Paper Spray Mass Spectrometry

被引：200

作者：

Wang, He ^{[1
]}

Manicke, Nicholas E. ^{[2
]}

Yang, Qian ^{[1
]}

Zheng, Lingxing ^{[3
]}

Shi, Riyi ^{[3
]}

Cooks, R. Graham ^{[2
,4
]}

Zheng Ouyang ^{[1
,4
]}

机构：

[1] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA

[2] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[3] Purdue Univ, Dept Basic Med Sci, Sch Vet Med, W Lafayette, IN 47907 USA

[4] Purdue Univ, Ctr Analyt Instrumentat Dev, W Lafayette, IN 47907 USA

来源：

ANALYTICAL CHEMISTRY | 2011年 / 83卷 / 04期

基金：

美国国家卫生研究院;

关键词：

IN-VIVO; DRUG DISTRIBUTION; ELECTROSPRAY; CANCER; CHROMATOGRAPHY; PHOSPHOLIPIDS; METABOLITES; BIOMARKER; SAMPLES; LIPIDS;

D O I：

10.1021/ac103150a

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Paper spray mass spectrometry (PS-MS) is explored as a fast and convenient way for direct analysis of molecules in tissues with minimum sample pretreatment. This technique allows direct detection of different types of compounds such as hormones, lipids, and therapeutic drugs in short total analysis times (less than 1 min) using a small volume of tissue sample (typically 1 mm(3) or less). The tissue sample could be obtained by needle aspiration biopsy, by punch biopsy, or by rubbing a thin tissue section across the paper. There exists potential for the application of paper spray mass spectrometry together with tissue biopsy for clinical diagnostics.

引用

页码：1197 / 1201

页数：5

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