Self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices

被引：92

作者：

Allain, Vanessa ^{[1
]}

Bourgaux, Claudie ^{[1
]}

Couvreur, Patrick ^{[1
]}

机构：

[1] Univ Paris 11, Lab Physicochim Pharmacotech & Biopharm, Fac Pharm, UMR CNRS 8612, F-92296 Chatenay Malabry, France

来源：

NUCLEIC ACIDS RESEARCH | 2012年 / 40卷 / 05期

基金：

欧洲研究理事会;

关键词：

IN-VIVO DELIVERY; MOLECULAR RECOGNITION; NUCLEOSIDE ANALOGS; GEMCITABINE; OPTIMIZATION; NUCLEOTIDE; PRODRUGS; DERIVATIVES; CHEMISTRY; LIPIDS;

D O I：

10.1093/nar/gkr681

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This short review aims at presenting some recent illustrative examples of spontaneous nucleolipids self-assembly. High-resolution structural investigations reveal the diversity and complexity of assemblies formed by these bioinspired amphiphiles, resulting from the interplay between aggregation of the lipid chains and base-base interactions. Nucleolipids supramolecular assemblies are promising soft drug delivery systems, particularly for nucleic acids. Regarding prodrugs, squalenoylation is an innovative concept for improving efficacy and delivery of nucleosidic drugs.

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页码：1891 / 1903

页数：13

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