Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

被引:594
作者
Gao, Hui-Ming [1 ]
Hong, Jau-Shyong [1 ]
机构
[1] NIEHS, Neuropharmacol Sect, Pharmacol Lab, Natl Inst Hlth, Res Triangle Pk, NC 27709 USA
关键词
D O I
10.1016/j.it.2008.05.002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Neurodegenerative diseases are a group of chronic, progressive disorders characterized by the gradual loss of neurons in discrete areas of the central nervous system (CNS). The mechanism(s) underlying their progressive nature remains unknown but a timely and well-controlled inflammatory reaction is essential for the integrity and proper function of the CNS. Substantial evidence has documented a common inflammatory mechanism in various neurodegenerative diseases. We hypothesize that in the diseased CNS, interactions between damaged neurons and dysregulated, overactivated microglia create a vicious self-propagating cycle causing uncontrolled, prolonged inflammation that drives the chronic progression of neurodegenerative diseases. We further propose that dynamic modulation of this inflammatory reaction by interrupting the vicious cycle might become a disease-modifying therapeutic strategy for neurodegenerative diseases.
引用
收藏
页码:357 / 365
页数:9
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