Neurodegenerative diseases are a group of chronic, progressive disorders characterized by the gradual loss of neurons in discrete areas of the central nervous system (CNS). The mechanism(s) underlying their progressive nature remains unknown but a timely and well-controlled inflammatory reaction is essential for the integrity and proper function of the CNS. Substantial evidence has documented a common inflammatory mechanism in various neurodegenerative diseases. We hypothesize that in the diseased CNS, interactions between damaged neurons and dysregulated, overactivated microglia create a vicious self-propagating cycle causing uncontrolled, prolonged inflammation that drives the chronic progression of neurodegenerative diseases. We further propose that dynamic modulation of this inflammatory reaction by interrupting the vicious cycle might become a disease-modifying therapeutic strategy for neurodegenerative diseases.
机构:Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
Qian, Li
Block, Michelle L.
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机构:Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
Block, Michelle L.
Wei, Sung-Jen
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机构:Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
Wei, Sung-Jen
Lin, Chiou-Feng
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机构:Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
Lin, Chiou-Feng
Reece, Jeffrey
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机构:Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
Reece, Jeffrey
Pang, Hao
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机构:Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
Pang, Hao
Wilson, Belinda
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机构:Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
Wilson, Belinda
Hong, Jau-Shyong
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机构:Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
Hong, Jau-Shyong
Flood, Patrick M.
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机构:
Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USAUniv N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
机构:Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
Qian, Li
Block, Michelle L.
论文数: 0引用数: 0
h-index: 0
机构:Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
Block, Michelle L.
Wei, Sung-Jen
论文数: 0引用数: 0
h-index: 0
机构:Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
Wei, Sung-Jen
Lin, Chiou-Feng
论文数: 0引用数: 0
h-index: 0
机构:Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
Lin, Chiou-Feng
Reece, Jeffrey
论文数: 0引用数: 0
h-index: 0
机构:Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
Reece, Jeffrey
Pang, Hao
论文数: 0引用数: 0
h-index: 0
机构:Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
Pang, Hao
Wilson, Belinda
论文数: 0引用数: 0
h-index: 0
机构:Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
Wilson, Belinda
Hong, Jau-Shyong
论文数: 0引用数: 0
h-index: 0
机构:Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA
Hong, Jau-Shyong
Flood, Patrick M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USAUniv N Carolina, Comprehens Ctr Inflammatory Disorders, Chapel Hill, NC 27599 USA