The first synthesis of enantiopure α-amino ketimines and amino aziridines

被引：30

作者：

Concellón, JM

Bernad, PL

Riego, E

García-Granda, S

Forcén-Acebal, A

机构：

[1] Univ Oviedo, Fac Quim, Dept Quim Organ & Inorgan, E-33071 Oviedo, Spain

[2] Univ Oviedo, Fac Quim, Dept Quim Fis & Analit, Oviedo 33071, Spain

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 66卷 / 08期

关键词：

D O I：

10.1021/jo005741x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral l-aminoalkyl chloromethyl ketimines 2 are synthesized in enantiomerically pure form starting from l-aminoalkyl chloromethyl ketones 1 and different amines. Reduction of amino ketimines 2 and subsequent spontaneus cyclization affords aminoalkyl aziridines 3 with high diastereoisomeric excess and without detectable racemization.

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页码：2764 / 2768

页数：5

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