Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators

被引:149
作者
de Azeredo, Elzinandes Leal [1 ]
Monteiro, Robson Q. [2 ]
de-Oliveira Pinto, Luzia Maria [1 ]
机构
[1] Fiocruz MS, IOC, Lab Imunol Viral, BR-21040360 Rio De Janeiro, RJ, Brazil
[2] Univ Fed Rio de Janeiro, Inst Bioquim Med Leopoldo de Meis, BR-21941599 Rio De Janeiro, RJ, Brazil
关键词
PROTEASE-ACTIVATED RECEPTORS; FACTOR PATHWAY INHIBITOR; TISSUE FACTOR; HEMORRHAGIC-FEVER; NITRIC-OXIDE; PLATELET-AGGREGATION; TNF-ALPHA; TRANSFORMING GROWTH-FACTOR-BETA-1; BRAZILIAN PATIENTS; PLASMA LEAKAGE;
D O I
10.1155/2015/313842
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Dengue is an infectious disease caused by dengue virus (DENV). In general, dengue is a self-limiting acute febrile illness followed by a phase of critical defervescence, in which patients may improve or progress to a severe form. Severe illness is characterized by hemodynamic disturbances, increased vascular permeability, hypovolemia, hypotension, and shock. Thrombocytopenia and platelet dysfunction are common in both cases and are related to the clinical outcome. Different mechanisms have been hypothesized to explain DENV-associated thrombocytopenia, including the suppression of bone marrow and the peripheral destruction of platelets. Studies have shown DENV-infected hematopoietic progenitors or bone marrow stromal cells. Moreover, anti-platelet antibodies would be involved in peripheral platelet destruction as platelets interact with endothelial cells, immune cells, and/or DENV. It is not yet clear whether platelets play a role in the viral spread. Here, we focus on the mechanisms of thrombocytopenia and platelet dysfunction in DENV infection. Because platelets participate in the inflammatory and immune response by promoting cytokine, chemokine, and inflammatory mediator secretion, their relevance as "immune-like effector cells" will be discussed. Finally, an implication for platelets in plasma leakage will be also regarded, as thrombocytopenia is associated with clinical outcome and higher mortality.
引用
收藏
页数:16
相关论文
共 186 条
[101]   High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever [J].
Libraty, DH ;
Young, PR ;
Pickering, D ;
Endy, TP ;
Kalayanarooj, S ;
Green, S ;
Vaughn, DW ;
Nisalak, A ;
Ennis, FA ;
Rothman, AL .
JOURNAL OF INFECTIOUS DISEASES, 2002, 186 (08) :1165-1168
[102]  
Lin CF, 2001, J MED VIROL, V63, P143, DOI 10.1002/1096-9071(20000201)63:2<143::AID-JMV1009>3.0.CO
[103]  
2-L
[104]   Autoimmune pathogenesis in dengue virus infection [J].
Lin, Chiou-Feng ;
Wan, Shu-Wen ;
Cheng, Hsien-Jen ;
Lei, Huan-Yao ;
Lin, Yee-Shin .
VIRAL IMMUNOLOGY, 2006, 19 (02) :127-132
[105]   Dengue virus nonstructural protein NS1 binds to prothrombin/thrombin and inhibits prothrombin activation [J].
Lin, Shi-Wei ;
Chuang, Yung-Chun ;
Lin, Yee-Shin ;
Lei, Huan-Yao ;
Liu, Hsiao-Sheng ;
Yeh, Trai-Ming .
JOURNAL OF INFECTION, 2012, 64 (03) :325-334
[106]   Molecular mimicry between virus and host and its implications for dengue disease pathogenesis [J].
Lin, Yee-Shin ;
Yeh, Trai-Ming ;
Lin, Chiou-Feng ;
Wan, Shu-Wen ;
Chuang, Yung-Chun ;
Hsu, Tan-Kuei ;
Liu, Hsiao-Sheng ;
Liu, Ching-Chuan ;
Anderson, Robert ;
Lei, Huan-Yao .
EXPERIMENTAL BIOLOGY AND MEDICINE, 2011, 236 (05) :515-523
[107]   The active platelet: Translation and protein synthesis in anucleate cell [J].
Lindemann, Stephan ;
Gawaz, Meinrad .
SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2007, 33 (02) :144-150
[108]   The Usefulness of Clinical-Practice-Based Laboratory Data in Facilitating the Diagnosis of Dengue Illness [J].
Liu, Jien-Wei ;
Lee, Ing-Kit ;
Wang, Lin ;
Chen, Rong-Fu ;
Yang, Kuender D. .
BIOMED RESEARCH INTERNATIONAL, 2013, 2013
[109]   Expression pattern of protease activated receptors in lymphoid cells [J].
Lopez, Mercedes L. ;
Soriano-Sarabia, Natalia ;
Bruges, Gustavo ;
Marquez, Maria Elena ;
Preissner, Klaus T. ;
Schmitz, M. Lienhard ;
Hackstein, Holger .
CELLULAR IMMUNOLOGY, 2014, 288 (1-2) :47-52
[110]   Preventive transfusion in dengue shock syndrome - Is it necessary? [J].
Lum, LCS ;
Abdel-Latif, MEA ;
Goh, AYT ;
Chan, PWK ;
Lam, SK .
JOURNAL OF PEDIATRICS, 2003, 143 (05) :682-684