The VLDL receptor: an LDL receptor relative with eight ligand binding repeats, LR8

被引:28
作者
Nimpf, J
Schneider, WJ
机构
[1] Univ Vienna, Dept Mol Genet, A-1030 Vienna, Austria
[2] Bioctr Vienna, A-1030 Vienna, Austria
基金
奥地利科学基金会;
关键词
VDL receptor; LDL receptor relative; ligand binding repeats;
D O I
10.1016/S0021-9150(98)00172-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The discovery in 1992 of a member of the low density lipoprotein receptor (LDLR) family with eight ligand binding repeats (LR8) has raised more questions than have been answered to date. Here, we summarize the current status of knowledge about this intriguing molecule, generally termed VLDL receptor, at the molecular biological, cell biological, and physiological levels. On one hand, the wealth of reports concerning the role(s) of this receptor in lipoprotein metabolism in mammalian systems has revealed partially conflicting details, particularly in regards to its natural ligand(s) and site of action. On the other hand, molecular genetic and biochemical studies in the chicken have clearly demonstrated the multiple roles of LR8 in the physiology and reproduction of egg-laying species, and have generated insights into the evolutionary aspects of the LDLR gene family. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:191 / 202
页数:12
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