Ocular static and dynamic light scattering: a noninvasive diagnostic tool for eye research and clinical practice

被引:29
作者
Ansari, RR [1 ]
机构
[1] NASA, Lewis Res Ctr, Cleveland, OH 44135 USA
基金
美国国家卫生研究院; 美国国家航空航天局;
关键词
static light scattering; dynamic light scattering; cataract; age-related macular degeneration; diabetic retinopathy; Alzheimer's disease; ophthalmology; early detection; bioastronautics; telemedicine; ocular disease;
D O I
10.1117/1.1626663
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The noninvasive techniques of static and dynamic light scattering are emerging as valuable diagnostic tools for the early detection of ocular and systemic diseases. These include corneal abnormalities, pigmentary dispersion syndrome, glaucoma, cataract, diabetic vitreopathy, and possibly macular degeneration. Systemic conditions such as diabetes and possibly Alzheimer's disease can potentially be detected early via ocular tissues. The current state of development of these techniques for application to ophthalmic research and ultimately clinical practice is reviewed. (C) 2004 society of Photo-Optical Instrumentation Engineers.
引用
收藏
页码:22 / 37
页数:16
相关论文
共 53 条
[1]  
*AM AC OPHTH, 1989, BAS CLIN SCI COUR 19, P107
[2]   Non-invasive and remote detection of cataracts during space exploration with dynamic light scattering [J].
Ansari, RR ;
Giblin, F ;
King, JF ;
Lambert, LM .
OPHTHALMIC TECHNOLOGIES XI, 2001, 4245 :129-134
[3]   Early detection of cataract and response to pantethine therapy with non-invasive static and dynamic light scattering [J].
Ansari, RR ;
King, JF ;
Seeberger, T ;
Clark, JI .
OPHTHALMIC TECHNOLOGIES XIII, 2003, 4951 :168-176
[4]   A fiber optic probe for monitoring protein aggregation, nucleation and crystallization [J].
Ansari, RR ;
Suh, KI ;
Arabshahi, A ;
Wilson, WW ;
Bray, TL ;
DeLucas, LJ .
JOURNAL OF CRYSTAL GROWTH, 1996, 168 (1-4) :216-226
[5]   Non-invasive evaluation of corneal abnormalities using static and dynamic light scattering [J].
Ansari, RR ;
Misra, AK ;
Leung, AB ;
King, JF ;
Datiles, MB .
OPHTHALMIC TECHNOLOGIES XII, 2002, 4611 :220-229
[6]   Celestial and terrestrial tele-ophthalmology: A health monitoring helmet for astronaut/cosmonaut and general public use [J].
Ansari, RR ;
Rovati, L ;
Sebag, J .
OPHTHALMIC TECHNOLOGIES XI, 2001, 4245 :177-185
[7]   Quantitative molecular characterization of bovine vitreous and lens with non-invasive dynamic light scattering [J].
Ansari, RR ;
Suh, KI ;
Dunker, S ;
Kitaya, N ;
Sebag, J .
EXPERIMENTAL EYE RESEARCH, 2001, 73 (06) :859-866
[8]   In-vivo "cataractograms" using a compact backscatter dynamic light scattering (DLS) probe [J].
Ansari, RR ;
Suh, KI ;
Tumminia, SJ ;
Russell, P ;
Zigler, JS .
MEDICAL APPLICATIONS OF LASERS IN DERMATOLOGY, OPHTHALMOLOGY, DENTISTRY, AND ENDOSCOPY, PROCEEDINGS OF, 1997, 3192 :202-210
[9]  
BALAZS EA, 1984, EYE A, V1, P533
[10]   Theoretical and experimental basis for the inhibition of cataract [J].
Benedek, GB ;
Pande, J ;
Thurston, GM ;
Clark, JI .
PROGRESS IN RETINAL AND EYE RESEARCH, 1999, 18 (03) :391-402