Receptor domains regulating μ opioid receptor uncoupling and internalization:: Relevance to opioid tolerance

被引:15
作者
Cox, BM [1 ]
Crowder, AT [1 ]
机构
[1] Uniformed Serv Univ Hlth Sci, Dept Pharmacol, Bethesda, MD 20814 USA
关键词
D O I
10.1124/mol.65.3.492
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
[No abstract available]
引用
收藏
页码:492 / 495
页数:4
相关论文
共 26 条
[11]   Threonine 180 is required for G-protein-coupled receptor kinase 3- and β-arrestin 2-mediated desensitization of the μ-opioid receptor in Xenopus oocytes [J].
Celver, JP ;
Lowe, J ;
Kovoor, A ;
Gurevich, VV ;
Chavkin, C .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (07) :4894-4900
[12]   Regulation of opioid receptor function by chronic agonist exposure: Constitutive activity and desensitization [J].
Chavkin, C ;
McLaughlin, JP ;
Celver, JP .
MOLECULAR PHARMACOLOGY, 2001, 60 (01) :20-25
[13]   NMR structure of the second intracellular loop of the α2A adrenergic receptor:: Evidence for a novel cytoplasmic helix [J].
Chung, DA ;
Zuiderweg, ERP ;
Fowler, CB ;
Soyer, OS ;
Mosberg, HI ;
Neubig, RR .
BIOCHEMISTRY, 2002, 41 (11) :3596-3604
[14]  
Haberstock-Debic H, 2003, J NEUROSCI, V23, P4324
[15]   Regulation of opioid receptor trafficking and morphine tolerance by receptor oligornerization [J].
He, L ;
Fong, J ;
von Zastrow, M ;
Whistler, JL .
CELL, 2002, 108 (02) :271-282
[16]   Morphine activates opioid receptors without causing their rapid internalization [J].
Keith, DE ;
Murray, SR ;
Zaki, PA ;
Chu, PC ;
Lissin, DV ;
Kang, L ;
Evans, CJ ;
vonZastrow, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (32) :19021-19024
[17]  
Luttrell LM, 2002, J CELL SCI, V115, P455
[18]   μ-opioid receptor desensitization -: Role of receptor phosphorylation, internalization, and resensitization [J].
Qiu, Y ;
Law, PY ;
Loh, HH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (38) :36733-36739
[19]   G-protein-coupled receptor dimerization: modulation of receptor function [J].
Rios, CD ;
Jordan, BA ;
Gomes, I ;
Devi, LA .
PHARMACOLOGY & THERAPEUTICS, 2001, 92 (2-3) :71-87
[20]   A novel endocytic recycling signal that distinguishes the membrane trafficking of naturally occurring opioid receptors [J].
Tanowitz, M ;
von Zastrow, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (46) :45978-45986