Multi-component coupling reactions:: synthesis of a guanidine containing analog of the hexahydropyrrolo[3,2-c] quinoline alkaloid martinelline

被引：87

作者：

Batey, RA ^{[1
]}

Powell, DA ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 22期

关键词：

D O I：

10.1039/b107431h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A multi-component coupling reaction is used to synthesize a highly functionalized guanidine containing pyrroloquinoline analog of martinelline that displays bradykinin B2 receptor antagonist activity.

引用

页码：2362 / 2363

页数：2

共 25 条

[11] Synthesis of 1,2,3-Trisubstituted pyrrolo[3,2-c]quinolines via palladium-catalyzed heteroannulation with internal alkynes [J].

Kang, SK ;

Park, SS ;

Kim, SS ;

Choi, JK ;

Yum, EK .

TETRAHEDRON LETTERS, 1999, 40 (23) :4379-4382

[12]

KOBAYASHI S, 1995, SYNTHESIS-STUTTGART, P1195

[13] An approach to the pyrroloquinoline core of martinelline and martinellic acid [J].

Lovely, CJ ;

Mahmud, H .

TETRAHEDRON LETTERS, 1999, 40 (11) :2079-2082

[14] First total synthesis of martinellic acid, a naturally occurring bradykinin receptor antagonist [J].

Ma, DW ;

Xia, CF ;

Jiang, JQ ;

Zhang, JH .

ORGANIC LETTERS, 2001, 3 (14) :2189-2191

[15] An intramolecular azomethine ylide-alkene cycloaddition approach to pyrrolo[3,2-c]quinolines-synthesis of a C2-truncated martinelline model [J].

Mahmud, H ;

Lovely, CJ ;

Dias, HVR .

TETRAHEDRON, 2001, 57 (19) :4095-4105

[16] Enantioselective synthesis of the pyrroloquinoline core of the martinellines [J].

Nieman, JA ;

Ennis, MD .

ORGANIC LETTERS, 2000, 2 (10) :1395-1397

[17] New synthetic route of guanidine from trichloroacetamide for tetrodotoxin and its related compounds. [J].

Nishikawa, T ;

Ohyabu, N ;

Yamamoto, N ;

Isobe, M .

TETRAHEDRON, 1999, 55 (14) :4325-4340

[18]

Nishikawa T, 1999, ANGEW CHEM INT EDIT, V38, P3081, DOI 10.1002/(SICI)1521-3773(19991018)38:20<3081::AID-ANIE3081>3.0.CO

[19]

2-6

[20] An intermolecular 1,3-dipolar cycloaddition approach to the tricyclic core of martinelline and martinellic acid [J].

Nyerges, M ;

Fejes, I ;

Toke, L .

TETRAHEDRON LETTERS, 2000, 41 (41) :7951-7954

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