Increased noradrenaline release from rat preoptic area during and after sevoflurane and isoflurane anesthesia

被引：25

作者：

Anzawa, N ^{[1
]}

Kushikata, T ^{[1
]}

Ohkawa, H ^{[1
]}

Yoshida, H ^{[1
]}

Kubota, T ^{[1
]}

Matsuki, A ^{[1
]}

机构：

[1] Hirosaki Univ, Sch Med, Dept Anesthesiol, Hirosaki, Aomori 0368562, Japan

来源：

CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE | 2001年 / 48卷 / 05期

关键词：

D O I：

10.1007/BF03028309

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Purpose: To study the effects of sevoflurane and isoflurane on noradrenaline release from the rat preoptic area (POA). Method: Sixteen male Wistar rats were studied. A microdialysis probe with a 2 mm long semipermeable membrane was implanted in the POA. Dialysates were collected at intervals often minutes. After obtaining five control samples for 50 min. 30 min inhalation of 3% sevoflurane or 1.8% isoflurane was performed. After cessation of the inhalation, five more samples were obtained for 50 min as recovery phase. Noradrenaline (NA) concentration in the dialysates was measured by high pressure liquid chromatography with an electrochemical detector. Results: Both sevoflurane and isoflurane caused marked increases in NA release from the rat POA (sevoflurane 233% at 20 min. isoflurane 357% at ten minutes after the start of inhalation). The marked NA releases were also observed during the emergence from sevoflurane and isoflurane anesthesia (sevoflurane 269% at 20 min. isoflurane 368% at ten minutes in the recovery phase). Conclusion: This study suggests that enhanced release of NA in the POA during sevoflurane and isoflurane may explain the excitatory phase observed during the peri-anesthetic period with these agents.

引用

页码：462 / 465

页数：4

共 27 条

[11] Physostigmine antagonizes ketamine-induced noradrenaline release from the medial prefrontal cortex in rats [J].

Kubota, T ;

Hirota, K ;

Anzawa, N ;

Yoshida, H ;

Kushikata, T ;

Matsuki, A .

BRAIN RESEARCH, 1999, 840 (1-2) :175-178

[12] SLEEP-INDUCING FUNCTION OF NORADRENERGIC FIBERS IN THE MEDIAL PREOPTIC AREA [J].

KUMAR, VM ;

SHARMA, R ;

WADHWA, S ;

MANCHANDA, SK .

BRAIN RESEARCH BULLETIN, 1993, 32 (02) :153-158

[13]

KUSHIKATA T, 1997, J JAPANESE SOC PHARM, V10, P3

[14] Sleep induction by microinjection of pentobarbital into the medial preoptic area in rats [J].

Mendelson, WB .

LIFE SCIENCES, 1996, 59 (22) :1821-1828

[15] CHARACTERIZATION OF THE HYPNOTIC EFFECTS OF TRIAZOLAM MICROINJECTIONS INTO THE MEDIAL PREOPTIC AREA [J].

MENDELSON, WB ;

MARTIN, JV .

LIFE SCIENCES, 1992, 50 (15) :1117-1128

[16] PENTOBARBITAL SODIUM INHIBITS THE RELEASE OF NORADRENALINE IN THE MEDIAL PREOPTIC AREA IN THE RAT [J].

MIZUNO, T ;

ITO, E ;

KIMURA, F .

NEUROSCIENCE LETTERS, 1994, 170 (01) :111-113

[17]

OHKAWA H, 1995, ANESTH ANALG, V81, P1289

[18] STRESS-INDUCED NOREPINEPHRINE RELEASE IN THE PARAVENTRICULAR NUCLEUS OF RATS WITH BRAIN-STEM HEMISECTIONS - A MICRODIALYSIS STUDY [J].

PACAK, K ;

PALKOVITS, M ;

KVETNANSKY, R ;

KOPIN, IJ ;

GOLDSTEIN, DS .

NEUROENDOCRINOLOGY, 1993, 58 (02) :196-201

[19]

Paxinos G., 1986, RAT BRAIN STEREOTAXI, Vsecond

[20] CARDIOVASCULAR-RESPONSES OF RATS TO INTRAHYPOTHALAMIC INJECTION OF CARBACHOL AND NORADRENALINE [J].

POOLE, S .

BRITISH JOURNAL OF PHARMACOLOGY, 1983, 79 (03) :693-700

← 1 2 3 →