Highly efficient ruthenium-catalyzed oxime to amide rearrangement

被引：244

作者：

Owston, Nathan A.

Parker, Alexandra J.

Williams, Jonathan M. J. ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] Avlon Works, AstraZeneca, Proc Res & Dev, Bristol BS10 7ZE, Avon, England

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 18期

关键词：

D O I：

10.1021/ol701445n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A wide range of aldoximes has been converted into the corresponding amides using the ruthenium-based catalyst Ru(PPh3)(3)(CO)H-2/dppe/TsOH. The amides are generated in high yield and selectivity, with catalyst loading as low as 0.04 mol %.

引用

页码：3599 / 3601

页数：3

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