Patient-specific cytotoxic T-lymphocyte cross-recognition of naturally occurring variants of a human immunodeficiency virus type 1 (HIV-1) p24gag epitope by HIV-1-infected children

被引：12

作者：

Buseyne, F

Chaix, ML

Rouzioux, C

Blanche, S

Rivière, Y

机构：

[1] Inst Pasteur, Dept SIDA & Retrovirus, Lab Immunopathol Virale, CNRS,URA 1930, F-75015 Paris, France

[2] Hop Necker Enfants Malad, Virol Lab, F-75015 Paris, France

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 10期

关键词：

D O I：

10.1128/JVI.75.10.4941-4946.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We tested seven human immunodeficiency virus-infected children for their cytotoxic T-lymphocyte (CTL) activities towards the p24(gag) QASQEVKNW epitope and its nine variant sequences. Our data confirm that most, but not all, CTL responses are broadly cross-specific. For the first time, we show the high interpatient variability in cross-recognition of mutant CTL epitopes. These interindividual variations in the CTL response to the same epitope should be taken into account in the design and the evaluation of vaccines.

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页码：4941 / 4946

页数：6

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