Hepatitis C Virus Infection in Pregnancy An Update

被引：12

作者：

Altinbas, Sibel ^{[1
]}

Holmes, Jacinta A. ^{[2
]}

Altinbas, Akif ^{[3
]}

机构：

[1] Hacettepe Univ, Dept Obstet & Gynecol, Kastamonu Med Fac, Ankara, Turkey

[2] St Vincents Hosp Melbourne, Dept Gastroenterol, Fitzroy, Vic, Australia

[3] Numune Educ & Res Hosp, Gastroenterol Clin, TR-06010 Ankara, Turkey

来源：

GASTROENTEROLOGY NURSING | 2020年 / 43卷 / 01期

关键词：

TO-CHILD-TRANSMISSION; HCV VERTICAL TRANSMISSION; RISK-FACTORS; INFANT TRANSMISSION; PERINATAL TRANSMISSION; SPONTANEOUS CLEARANCE; CRYSTAL-STRUCTURE; NATURAL-HISTORY; BLOOD-DONORS; VIRAL LOAD;

D O I：

10.1097/SGA.0000000000000404

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Parenteral transmission is the major route of hepatitis C virus transmission in adults; however, vertical transmission is most common in children. There are several factors that have been shown to be associated with vertical transmission of hepatitis C virus, including hepatitis C virus RNA, human immunodeficiency virus coinfection, and peripheral blood mononuclear cell infection. As there is no effective vaccine to prevent hepatitis C virus infection, and there are no human data describing the safety of the new direct acting antiviral agents in pregnancy, the only preventive strategy for vertical transmission is to treat the hepatitis C virus infection before becoming pregnant. Direct acting antiviral agents are interferon-free, and many are also ribavirin-free. Based on animal studies, sofosbuvir plus ledipasvir may be the best safety profile during pregnancy for now; however, it is too early to recommend treating hepatitis C virus-infected pregnant women with these direct acting antiviral agents currently.

引用

页码：12 / 21

页数：10

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