A pyrene-labeled G-quadruplex oligonucleotide as a fluorescent probe for potassium ion detection in biological applications

被引：183

作者：

Nagatoishi, S

Nojima, T

Juskowiak, B

Takenaka, S ^{[1
]}

机构：

[1] Kyushu Inst Technol, Dept Mat Sci, Fac Engn, Kitakyushu, Fukuoka 8048550, Japan

[2] Kyushu Univ, Fac Engn, Dept Appl Chem, Fukuoka 812858, Japan

[3] Adam Mickiewicz Univ, Fac Chem, PL-60780 Poznan, Poland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 32期

关键词：

alkali metals; DNA structures; excimer emission; fluorescent probes; potassium;

D O I：

10.1002/anie.200501506

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Ion probes: A potassium-sensing oligonucleotide with terminal pyrene moieties can be used as a fluorescent probe for the real-time monitoring of the extracellular concentration of K+ ions under physiological conditions. The excimer emission intensity (b) of the chair-type quadruplex structure formed depends on the K+ ion concentration (0-200 mM), and differs significantly from that in the absence of potassium (a). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：5067 / 5070

页数：4

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