Novel neural adhesion molecules in the Contactin/F3 subgroup of the immunoglobulin superfamily: Isolation and characterization of cDNAs from rat brain

被引：57

作者：

Ogawa, J

Kaneko, H

Masuda, T

Nagata, S

Hosoya, H

Watanabe, K

机构：

[1] TOKYO METROPOLITAN INST GERONTOL,DEPT EXPT BIOL,ITABASHI KU,TOKYO 173,JAPAN

[2] JAPAN WOMENS UNIV,BUNKYO KU,TOKYO 112,JAPAN

来源：

NEUROSCIENCE LETTERS | 1996年 / 218卷 / 03期

关键词：

immunoglobulin superfamily; GPI-anchor; Contactin; F3; neural adhesion; brain development; NB-2; NB-3;

D O I：

10.1016/S0304-3940(96)13156-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We cloned two kinds of cDNAs encoding novel Contactin/F3-subgroup adhesion molecules, which we termed NB-2 and NB-3. Nucleotide sequence analyses have shown that NB-2 and NB-3 are comprised of 1099 and 1028 amino acid residues, respectively. There was 51% similarity in the amino acid sequence of NB-2 and NB-3. NB-2 shared 46, 43, 55 and 55% identities with Contactin/F3, Tag-1, Big-1 and Big-2, respectively, at the amino acid sequence level. Likewise, the amino acid sequence of NB-3 exhibited 42, 44, 58 and 60% identities with Contactin/F3, Tag-1, Big-1 and Big-2, respectively. Expression of NB-2 mRNA was restricted to cerebrum, cerebellum and was hardly detectable, if any, in spinal cord. On the other hand, high expression of NB-3 mRNA was observed in spinal cord, as well as in cerebrum and cerebellum. In the other tissues, no expression of NB-2 and NB-3 mRNAs was detected.

引用

页码：173 / 176

页数：4

共 21 条

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