Neoclerodane diterpenes as a novel scaffold for μ opioid receptor ligands

被引：122

作者：

Harding, WW

Tidgewell, K

Byrd, N

Cobb, H

Dersch, CM

Butelman, ER

Rothman, RB

Prisinzano, TE ^{[1
]}

机构：

[1] Univ Iowa, Coll Pharm, Div Med & Nat Prod Chem, Iowa City, IA 52242 USA

[2] NIDA, Clin Psychopharmacol Sect, IRP, NIH,DHHS, Baltimore, MD 21224 USA

[3] Rockefeller Univ, Lab Biol Adict Dis, New York, NY 10021 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 48卷 / 15期

关键词：

D O I：

10.1021/jm048963m

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structural modification of salvinorin A, the active component of Salvia divinorum, has resulted in the synthesis of novel neoclerodane diterpenes with opioid receptor affinity and activity. We report in this study a nonnitrogenous neoclerodane diterpene with mu opioid receptor affinity (13) that is an agonist at mu opioid receptors. This represents the identification of a novel structural class of mu opioid receptor agonists.

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页码：4765 / 4771

页数：7

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