A high-resolution consensus linkage map of the rat, integrating radiation hybrid and genetic maps

被引：26

作者：

Bihoreau, MT

Sebag-Montefiore, L

Godfrey, RF

Wallis, RH

Brown, JH

Danoy, PA

Collins, SC

Rouard, M

Kaisaki, PJ

Lathrop, M

Gauguier, D

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[2] Natl Ctr Genotyping, Evry, France

来源：

GENOMICS | 2001年 / 75卷 / 1-3期

基金：

英国惠康基金;

关键词：

rat; linkage mapping; radiation hybrid mapping; comparative mapping; quantitative trait locus;

D O I：

10.1006/geno.2001.6583

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have constructed a high-resolution consensus genetic map of the rat in a single large intercross, which integrates 747 framework markers and 687 positions of our whole-genome radiation hybrid (RH) map of the rat. We selected 136 new gene markers from the GenBank database and assigned them either genetically or physically to rat chromosomes to evaluate the accuracy of the integrated linkage-RH maps in the localization of new markers and to enrich existing comparative mapping data. These markers and 631 D-Got- markers, which are physically mapped but still uncharacterized for evidence of polymorphism, were tested for allele variations in a panel of 16 rat strains commonly used in genetic studies. The consensus linkage map constructed in the GK x BN cross now comprises 1620 markers of various origins, defining 840 resolved genetic positions with an average spacing of 2.2 cM between adjacent loci, and includes 407 gene markers. This whole-genome genetic map will contribute to the advancement of genetic studies in the rat by incorporating gene/EST maps, physical mapping information, and sequence data generated in rat and other mammalian species into genetic intervals harboring disease susceptibility loci identified in rat models of human genetic disorders.

引用

页码：57 / 69

页数：13

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