An anchored YAC-STS framework for the rat genome

被引：1

作者：

Cai, L

Lindpaintner, K

Browne, J

Gruetzner, F

Haaf, T

James, MR

Bihoreau, MT

机构：

[1] Brigham & Womens Hosp, Dept Med, Div Cardiovasc, Boston, MA 02115 USA

[2] Childrens Hosp, Dept Cardiol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[4] F Hoffmann La Roche & Co Ltd, Roche Genet, Div Pharmaceut, CH-4002 Basel, Switzerland

[5] Max Delbruck Ctr Mol Med, Berlin, Germany

[6] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England

[7] Max Planck Inst Mol Genet, Berlin, Germany

来源：

CYTOGENETICS AND CELL GENETICS | 2000年 / 89卷 / 3-4期

关键词：

D O I：

10.1159/000015606

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We report here the first YAC-STS framework for the rat genome. A total of 417 anchor microsatellite markers were used to screen a 10-fold redundant YAC library. One or more unambiguous YACs were identified for 372 markers. Assuming the genetic length of the rat genome to be 2,000 cM (Bihoreau et al, 1997b), the YAC-STS framework will provide, on average, one informative YAC clone every 5.4 cM, A total of 111 anchor markers used in this study were derived from known gene regions. We also demonstrated one of the important and immediate uses of this YAC-STS framework, which is to establish a correlation between the genetic and cytogenetic maps in the rat through FISH analysis. Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：168 / 170

页数：3

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