Suppression of feline immunodeficiency virus replication in vitro by a soluble factor secreted by CD8+ T lymphocytes

被引：26

作者：

Flynn, JN ^{[1
]}

Cannon, CA ^{[1
]}

Sloan, D ^{[1
]}

Neil, JC ^{[1
]}

Jarrett, O ^{[1
]}

机构：

[1] Univ Glasgow, Dept Vet Pathol, Glasgow G61 1QH, Lanark, Scotland

来源：

IMMUNOLOGY | 1999年 / 96卷 / 02期

关键词：

D O I：

10.1046/j.1365-2567.1999.00690.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mitogen-activated lymphoblasts isolated from the blood and lymph nodes, but not the spleen, of domestic cats acutely infected with the Petaluma or Glasgow, isolates of feline immunodeficiency virus (FIV), suppressed the replication of FIV in the MYA-1 T-cell line in a dose-dependent manner. This effect was not limited to the homologous isolate of FIV. The suppressor activity declined with progression to chronic infection, with lower levels of activity detectable only in the lymph nodes. Immunization of domestic cats with whole inactivated FIV vaccine elicited profound suppressor activity in both the blood and lymph nodes. The suppressor activity was associated with the CD8(+) T-cell subpopulation, the effect did not appear to be major histocompatibility complex-restricted, and was mediated by a soluble factor(s). This activity may be associated with the control of virus replication during both the asymptomatic stages of FIV infection, and in the protective immunity observed in cats immunized with whole inactivated virus vaccines.

引用

页码：220 / 229

页数：10

共 41 条

[21] AN ACTIVATED CD8+ T-CELL PHENOTYPE CORRELATES WITH ANTI-HIV ACTIVITY AND ASYMPTOMATIC CLINICAL STATUS [J].

LANDAY, AL ;

MACKEWICZ, CE ;

LEVY, JA .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1993, 69 (01) :106-116

[22] IMMUNIZATION-INDUCED DECREASE OF THE CD4+-CD8+ RATIO IN CATS EXPERIMENTALLY INFECTED WITH FELINE IMMUNODEFICIENCY VIRUS [J].

LEHMANN, R ;

VONBEUST, B ;

NIEDERER, E ;

CONDRAU, MA ;

FIERZ, W ;

AUBERT, A ;

ACKLEY, CD ;

COOPER, MD ;

TOMPKINS, MB ;

LUTZ, H .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1992, 35 (1-2) :199-214

[23] Controlling HIV pathogenesis: The role of the noncytotoxic anti-HIV response of CD8(+) T cells [J].

Levy, JA ;

Mackewicz, CE ;

Barker, E .

IMMUNOLOGY TODAY, 1996, 17 (05) :217-224

[24] CD8+ CELL ANTI-HIV ACTIVITY - NONLYTIC SUPPRESSION OF VIRUS-REPLICATION [J].

MACKEWICZ, C ;

LEVY, JA .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1992, 8 (06) :1039-1050

[25] EFFECT OF CYTOKINES ON HIV REPLICATION IN CD4(+) LYMPHOCYTES - LACK OF IDENTITY WITH THE CD8(+) CELL ANTIVIRAL FACTOR [J].

MACKEWICZ, CE ;

ORTEGA, H ;

LEVY, JA .

CELLULAR IMMUNOLOGY, 1994, 153 (02) :329-343

[26]

MIYAZAWA TM, 1989, ARCH VIROL, V198, P131

[27]

NIXON DF, 1992, IMMUNOLOGY, V76, P515

[28] Inhibition of HIV-1 infection by the beta-chemokine MDC [J].

Pal, R ;

GarzinoDemo, A ;

Markham, PD ;

Burns, J ;

Brown, M ;

Gallo, RC ;

DeVico, AL .

SCIENCE, 1997, 278 (5338) :695-698

[29] Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures [J].

Paxton, WA ;

Martin, SR ;

Tse, D ;

OBrien, TR ;

Skurnick, J ;

VanDevanter, NL ;

Padian, N ;

Braun, JF ;

Kotler, DP ;

Wolinsky, SM ;

Koup, RA .

NATURE MEDICINE, 1996, 2 (04) :412-417

[30] HIGH-LEVELS OF ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) MEMORY CYTOTOXIC T-LYMPHOCYTE ACTIVITY AND LOW VIRAL LOAD ARE ASSOCIATED WITH LACK OF DISEASE IN HIV-1-INFECTED LONG-TERM NONPROGRESSORS [J].

RINALDO, C ;

HUANG, XL ;

FAN, Z ;

DING, M ;

BELTZ, L ;

LOGAR, A ;

PANICALI, D ;

MAZZARA, G ;

LIEBMANN, J ;

COTTRILI, M ;

GUPTA, P .

JOURNAL OF VIROLOGY, 1995, 69 (09) :5838-5842

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