Domain III peptides from flavivirus envelope protein are useful antigens for serologic diagnosis and targets for immunization

被引：114

作者：

Chavez, Juliana Helena ^{[1
]}

Silva, Jaqueline Raymondi ^{[1
]}

Amarilla, Alberto Anastacio ^{[1
]}

Moraes Figueiredo, Luiz Tadeu ^{[1
]}

机构：

[1] Univ Sao Paulo, Virol Res Ctr, Sch Med Ribeirao Preto, FMRP, BR-14049900 Ribeirao Preto, SP, Brazil

来源：

BIOLOGICALS | 2010年 / 38卷 / 06期

关键词：

Flaviviruses; Envelope protein; Domain III; Diagnostic tests; Flavivirus vaccine; BORNE ENCEPHALITIS-VIRUS; RECOMBINANT FUSION PROTEIN; WEST-NILE; MONOCLONAL-ANTIBODY; CRYSTAL-STRUCTURE; NEUTRALIZING ANTIBODIES; MOSQUITO-BORNE; BINDING; GLYCOPROTEIN; EPITOPES;

D O I：

10.1016/j.biologicals.2010.07.004

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The Flavivirus genus of the Flaviviridae family Includes 70 enveloped single-stranded-RNA positive-sense viruses transmitted by arthropods Among these viruses there are a relevant number of human pathogens including the mosquito-borne dengue virus (DENV) yellow fever virus (YFV) Japanese encephalitis virus (JEV) and West Nile virus (WNV) as well as tick-borne viruses such as tick-borne encephalitis virus (TBEV) Langat virus (LGTV) and Omsk hemorrhagic fever (OHFV) The flavivirus envelope (E) protein is a dominant antigen inducing immunologic responses in Infected hosts and eliciting virus-neutralizing antibodies The domain III (DIII) of E protein contains a panel of Important epitopes that are recognized by virus-neutralizing monoclonal antibodies Peptides of the DIII have been used with promising results as antigens for flavivirus serologic diagnosis and as targets for immunization against these viruses We review here some important aspects of the molecular structure of the DIII as well as its use as antigens for serologic diagnosis and immunization in animal models (C) 2010 The International Association for Biologicals Published by Elsevier Ltd All rights reserved

引用

页码：613 / 618

页数：6

共 56 条

[1] Immunogenicity and protective efficacy of the E-coli-expressed domain III of Japanese encephalitis virus envelope protein in mice [J].