Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to β-lactams

被引：118

作者：

Nishino, K

Yamada, J

Hirakawa, H

Hirata, T

Yamaguchi, A

机构：

[1] Osaka Univ, Inst Sci & Ind Res, Dept Cell Membrane Biol, Ibaraki, Osaka 5670047, Japan

[2] Japan Sci & Technol Corp, CREST, Ibaraki, Osaka 5670047, Japan

[3] Osaka Univ, Fac Pharmaceut Sci, Osaka 5650871, Japan

[4] Osaka Univ, Microbial Dis Res Inst, Dept Bacterial Infect, Osaka 5650871, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 09期

关键词：

D O I：

10.1128/AAC.47.9.3030-3033.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

AcrAB exports some beta-lactam antibiotics in the periplasm out of cells via an outer-membrane channel, TolC. It has been reported that eight drug transporters in Escherichia coli cooperate with TolC. In this study, the roles of the drug exporters of E. coli in beta-lactam resistance were examined. We found that five of five resistance-nodulation-cell division-type drug exporters confer beta-lactam antibiotic resistance, while no other drug exporters confer any beta-lactam resistance even when they cooperate with TolC.

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页码：3030 / 3033

页数：4

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