Synthesis of PLA-b-PEG multiblock copolymers for stealth drug carrier preparation.

被引:31
作者
Quesnel, R [1 ]
Hildgen, P [1 ]
机构
[1] Univ Montreal, Fac Pharm, Succursale Ctr Ville, Montreal, PQ H3C 3J7, Canada
关键词
copolymers; multiblock; lactic acid; polyethylene glycol;
D O I
10.3390/10010098
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
An efficient method of preparing biodegradable and biocompatible multiblock copolymers from lactic acid and polyethylene glycol is proposed.
引用
收藏
页码:98 / 104
页数:7
相关论文
共 15 条
[1]  
Celikkaya E, 1996, ARTIF ORGANS, V20, P743
[2]   BIODEGRADABLE PEO/PLA BLOCK COPOLYMERS [J].
COHN, D ;
YOUNES, H .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1988, 22 (11) :993-1009
[3]   SYNTHESIS AND PROPERTIES OF NOVEL BLOCK-COPOLYMERS CONTAINING POLY(LACTIC-GLYCOLIC ACID) AND POLY(ETHYLENEGLYCOL) SEGMENTS [J].
FERRUTI, P ;
PENCE, M ;
DADDATO, P ;
RANUCCI, E ;
DEGHENGHI, R .
BIOMATERIALS, 1995, 16 (18) :1423-1428
[4]   Biocompatibility of implantable synthetic polymeric drug carriers: focus on brain biocompatibility [J].
Fournier, E ;
Passirani, C ;
Montero-Menei, CN ;
Benoit, JP .
BIOMATERIALS, 2003, 24 (19) :3311-3331
[5]   The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices [J].
Jain, RA .
BIOMATERIALS, 2000, 21 (23) :2475-2490
[6]  
Muller R, 1991, COLLOIDAL CARRIERS C, P45
[7]   Injectable microcapsules prepared with biodegradable poly(alpha-hydroxy) acids for prolonged release of drugs [J].
Ogawa, Y .
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 1997, 8 (05) :391-409
[8]   Injectable nanospheres from a novel multiblock copolymer:: cytocompatibility, degradation and in vitro release studies [J].
Panoyan, A ;
Quesnel, R ;
Hildgen, P .
JOURNAL OF MICROENCAPSULATION, 2003, 20 (06) :745-758
[9]   Hydrogels as mucoadhesive and bioadhesive materials: A review [J].
Peppas, NA ;
Sahlin, JJ .
BIOMATERIALS, 1996, 17 (16) :1553-1561
[10]  
PISKIN E, 1995, J BIOMAT SCI-POLYM E, V7, P359