Configuration of the psymberin amide side chain

被引：37

作者：

Kiren, S ^{[1
]}

Williams, LJ ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 14期

关键词：

D O I：

10.1021/ol0508375

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structure of the amide side chain of psymberin, a potent and selective cytotoxin, is proposed. Syn and anti models of the amide side chain were prepared, and the structural assignment was confirmed by X-ray crystallographic analysis of the anti isomer. Comparison of H-1 and C-13 NMR data establishes homology between the natural product and the synthetic model compound of anti configuration and not the corresponding syn isomer.

引用

页码：2905 / 2908

页数：4

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