The end of the beginning for pluripotent stem cells

被引：224

作者：

Donovan, PJ ^{[1
]}

Gearhart, J

机构：

[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[2] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21287 USA

来源：

NATURE | 2001年 / 414卷 / 6859期

关键词：

D O I：

10.1038/35102154

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pluripotent stem cells can be expanded seemingly indefinitely in culture, maintain a normal karyotype and have the potential to generate any cell type in the body. As such they represent an incredible resource for the repair of diseased or damaged tissues in our bodies. These cells also promise to open a new window into the embryonic development of our species.

引用

页码：92 / 97

页数：6

共 78 条

[51] The genetic program of hematopoietic stem cells
Phillips, RL
Ernst, RE
Brunk, B
Ivanova, N
Mahan, MA
Deanehan, JK
Moore, KA
Overton, GC
Lemischka, IR
[J]. SCIENCE, 2000, 288 (5471) : 1635 - 1640
[52] LONG-TERM PROLIFERATION OF MOUSE PRIMORDIAL GERM-CELLS IN CULTURE
RESNICK, JL
BIXLER, LS
CHENG, LZ
DONOVAN, PJ
[J]. NATURE, 1992, 359 (6395) : 550 - 551
[53] Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro
Reubinoff, BE
Pera, MF
Fong, CY
Trounson, A
Bongso, A
[J]. NATURE BIOTECHNOLOGY, 2000, 18 (04) : 399 - 404
[54] ROSENTHA.MD, 1970, J NATL CANCER I, V44, P1001
[55] Embryotoxicity screening using embryonic stem cells in vitro: Correlation to in vivo teratogenicity
Scholz, G
Pohl, I
Genschow, E
Klemm, M
Spielmann, H
[J]. CELLS TISSUES ORGANS, 1999, 165 (3-4) : 203 - 211
[56] Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro
Shamblott, MJ
Axelman, J
Littlefield, JW
Blumenthal, PD
Huggins, GR
Cui, Y
Cheng, LZ
Gearhart, JD
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (01) : 113 - 118
[57] Derivation of pluripotent stem cells horn cultured human primordial germ cells
Shamblott, MJ
Axelman, J
Wang, SP
Bugg, EM
Littlefield, JW
Donovan, PJ
Blumenthal, PD
Huggins, GR
Gearhart, JD
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (23) : 13726 - 13731
[58] CARCINOMA-INSITU OF THE TESTIS - POSSIBLE ORIGIN FROM GONOCYTES AND PRECURSOR OF ALL TYPES OF GERM-CELL TUMORS EXCEPT SPERMATOCYTOMA
SKAKKEBAEK, NE
BERTHELSEN, JG
GIWERCMAN, A
MULLER, J
[J]. INTERNATIONAL JOURNAL OF ANDROLOGY, 1987, 10 (01): : 19 - +
[59] Smith A, 2001, COLD SPRING HARBOR M, P205
[60] INHIBITION OF PLURIPOTENTIAL EMBRYONIC STEM-CELL DIFFERENTIATION BY PURIFIED POLYPEPTIDES
SMITH, AG
HEATH, JK
DONALDSON, DD
WONG, GG
MOREAU, J
STAHL, M
ROGERS, D
[J]. NATURE, 1988, 336 (6200) : 688 - 690

← 1 2 3 4 5 6 7 8 →