Serine/threonine protein phosphatases PP1 and PP2A are key players in apoptosis

被引:146
作者
Garcia, A
Cayla, X
Guergnon, J
Dessauge, F
Hospital, V
Rebollo, MP
Fleischer, A
Rebollo, A
机构
[1] Inst Pasteur, Dept Parasitol, URA CNRS 2581, Lab Signalisat Immunoparasitaire, F-75015 Paris, France
[2] Univ Tours, UMR 6073 INRA CNRS, F-37380 Nouzilly, France
[3] Hosp Gen Leon, Leon, Spain
[4] Hop La Pitie Salpetriere, INSERM U543, Lab Immunol Cellulaire & Tissulaire, F-75013 Paris, France
关键词
apoptosis; PP1; PP2A; Bcl-2; bad;
D O I
10.1016/j.biochi.2003.09.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The reversible phosphorylation of proteins controlled by protein kinases and protein phosphatases is a major mechanism that regulates a wide variety of cellular processes. In contrast to C elegans, recent studies in mammalian cells have highlighted a major role of serine/threonine protein phosphorylation in apoptosis. To illustrate the importance of dephosphorylation processes in apoptosis, this review will focus on recent studies suggesting that the interaction of the serine/threonine protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) with certain regulators of the Bcl-2 family is critically involved in the control of apoptosis. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:721 / 726
页数:6
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