Design and discovery of nonpeptide endothelin antagonists

被引：26

作者：

Doherty, AM

机构：

[1] Department of Chemistry, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor

来源：

DRUG DISCOVERY TODAY | 1996年 / 1卷 / 02期

关键词：

D O I：

10.1016/1359-6446(96)89090-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The involvement of the endothelin family of peptide vasoconstrictors has been implicated in a variety of human disease stales. Several classes of endothelin antagonists are in early clinical development, and the therapeutic applications oi this new mechanistic class of agents are beginning to emerge. This article reviews the different compound classes, their receptor selectivity for the endothelin receptor subtypes ET(A) and ET(B) and some important studies of selected compounds in animal models of different disease states.

引用

页码：60 / 70

页数：11

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