Circulating 25-Hydroxyvitamin D and Risk of Pancreatic Cancer

被引：163

作者：

Stolzenberg-Solomon, Rachael Z. ^{[1
]}

Jacobs, Eric J. ^{[2
]}

Arslan, Alan A. ^{[3
]}

Qi, Dai ^{[4
]}

Patel, Alpa V. ^{[2
]}

Helzlsouer, Kathy J. ^{[5
,6
]}

Weinstein, Stephanie J. ^{[1
]}

McCullough, Marjorie L. ^{[2
]}

Purdue, Mark P. ^{[1
]}

Shu, Xiao-Ou ^{[4
]}

Snyder, Kirk ^{[7
]}

Virtamo, Jarmo ^{[8
]}

Wilkins, Lynn R. ^{[9
]}

Yu, Kai ^{[1
]}

Zeleniuch-Jacquotte, Anne ^{[3
]}

Zheng, Wei ^{[4
]}

Albanes, Demetrius ^{[1
]}

Cai, Qiuyin ^{[4
]}

Harvey, Chinonye ^{[10
]}

Hayes, Richard ^{[1
]}

Clipp, Sandra ^{[5
,6
]}

Horst, Ronald L. ^{[11
]}

Irish, Lonn ^{[7
]}

Koenig, Karen ^{[3
]}

Le Marchand, Loic ^{[9
]}

Kolonel, Laurence N. ^{[9
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20852 USA

[2] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[3] NYU, Dept Environm Med, Sch Med, New York, NY 10016 USA

[4] Vanderbilt Univ, Sch Med, Vanderbilt Epidemiol Ctr, Vanderbilt Ingram Canc Ctr,Div Epidemiol,Dept Med, Nashville, TN 37212 USA

[5] Mercy Med Ctr, Weinberg Ctr Womens Hlth & Med, Prevent & Res Ctr, Baltimore, MD USA

[6] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[7] Informat Management Serv Inc, Silver Spring, MD USA

[8] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland

[9] Univ Hawaii, Canc Res Ctr, Program Epidemiol, Honolulu, HI 96813 USA

[10] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA

[11] Heartland Assays Inc, Ames, IA USA

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2010年 / 172卷 / 01期

基金：

美国国家卫生研究院;

关键词：

case-control studies; cohort studies; pancreatic neoplasms; prospective studies; vitamin D; VITAMIN-D STATUS; D ANALOGS; MORTALITY; INSULIN; PROLIFERATION; EXPRESSION; DESIGN; COHORT; PREVENTION; RATIONALE;

D O I：

10.1093/aje/kwq120

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Results from epidemiologic studies examining pancreatic cancer risk and vitamin D intake or 25-hydroxyvitamin D (25(OH)D) concentrations (the best indicator of vitamin D derived from diet and sun) have been inconsistent. Therefore, the authors conducted a pooled nested case-control study of participants from 8 cohorts within the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP) (1974-2006) to evaluate whether prediagnostic circulating 25(OH)D concentrations were associated with the development of pancreatic cancer. In total, 952 incident pancreatic adenocarcinoma cases occurred among participants (median follow-up, 6.5 years). Controls (n = 1,333) were matched to each case by cohort, age, sex, race/ethnicity, date of blood draw, and follow-up time. Conditional logistic regression analysis was used to calculate smoking-, body mass index-, and diabetes-adjusted odds ratios and 95% confidence intervals for pancreatic cancer. Clinically relevant 25(OH)D cutpoints were compared with a referent category of 50-< 75 nmol/L. No significant associations were observed for participants with lower 25(OH)D status. However, a high 25(OH)D concentration (>= 100 nmol/L) was associated with a statistically significant 2-fold increase in pancreatic cancer risk overall (odds ratio = 2.12, 95% confidence interval: 1.23, 3.64). Given this result, recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer should be carefully considered.

引用

页码：81 / 93

页数：13

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