To cre or not to cre - The next generation of mouse models of human cardiac diseases

被引:26
作者
Chien, KR [1 ]
机构
[1] Univ Calif San Diego, Sch Med, Inst Mol Med, La Jolla, CA 92093 USA
关键词
transgenic mouse models; heart disease; cardiomyopathy; gene targeting; homologous recombination;
D O I
10.1161/01.RES.88.6.546
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:546 / 549
页数:4
相关论文
共 44 条
[1]   Gene recombination in postmitotic cells - Targeted expression of cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo [J].
Agah, R ;
Frenkel, PA ;
French, BA ;
Michael, LH ;
Overbeek, PA ;
Schneider, MD .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (01) :169-179
[2]   Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy [J].
Akhter, SA ;
Luttrell, LM ;
Rockman, HA ;
Iaccarino, G ;
Lefkowitz, RJ ;
Koch, WJ .
SCIENCE, 1998, 280 (5363) :574-577
[3]   MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure [J].
Arber, S ;
Hunter, JJ ;
Ross, J ;
Hongo, M ;
Sansig, G ;
Borg, J ;
Perriard, JC ;
Chien, KR ;
Caroni, P .
CELL, 1997, 88 (03) :393-403
[4]   A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance [J].
Bruning, JC ;
Michael, MD ;
Winnay, JN ;
Hayashi, T ;
Horsch, D ;
Accili, D ;
Goodyear, LJ ;
Kahn, CR .
MOLECULAR CELL, 1998, 2 (05) :559-569
[5]  
Bujard H, 1999, J GENE MED, V1, P372
[6]   Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 [J].
Carmeliet, P ;
Ng, YS ;
Nuyens, D ;
Theilmeier, G ;
Brusselmans, K ;
Cornelissen, I ;
Ehler, E ;
Kakkar, VV ;
Stalmans, I ;
Mattot, V ;
Perriard, JC ;
Dewerchin, M ;
Flameng, W ;
Nagy, A ;
Lupu, F ;
Moons, L ;
Collen, D ;
D'Amore, PA ;
Shima, DT .
NATURE MEDICINE, 1999, 5 (05) :495-502
[7]   Selective requirement of myosin light chain 2v in embryonic heart function [J].
Chen, J ;
Kubalak, SW ;
Minamisawa, S ;
Price, RL ;
Becker, KD ;
Hickey, R ;
Ross, J ;
Chien, KR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (02) :1252-1256
[8]  
Chen J, 1998, DEVELOPMENT, V125, P1943
[9]   Meeting Koch's postulates for calcium signaling in cardiac hypertrophy [J].
Chien, KR .
JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (10) :1339-1342
[10]   Genomic circuits and the integrative biology of cardiac diseases [J].
Chien, KR .
NATURE, 2000, 407 (6801) :227-232