Microelectrophoretic application of SCH-23390 into the lateral septal nucleus blocks ethanol-induced suppression of LTP, in vivo, in the adult rodent hippocampus

被引：9

作者：

Criado, JR ^{[1
]}

Steffensen, SC ^{[1
]}

Henriksen, SJ ^{[1
]}

机构：

[1] SCRIPPS RES INST, ALCOHOL RES CTR, DEPT NEUROPHARMACOL CVN13, LA JOLLA, CA 92037 USA

来源：

BRAIN RESEARCH | 1996年 / 716卷 / 1-2期

关键词：

alcohol; SCH-23390; SKF-38393; paired-pulse responses; lateral septal nucleus; dentate gyrus;

D O I：

10.1016/0006-8993(96)00018-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ethanol intoxication produces deficits in the acquisition of new information and blocks the induction of hippocampal long-term potentiation (LTP), a candidate neurophysiological correlate for learning and memory. We report that, in adult rats, local application of the dopamine (DA) D-1 receptor antagonist SCH-23390 into the lateral septum (LS) blocks ethanol-induced suppression of LTP and alterations of paired-pulse responses in the dentate gyrus. This suggests a primary role for an extra-hippocampal circuit and neurotransmitter system mediating ethanol's ability to suppress LTP.

引用

页码：192 / 196

页数：5

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