Icariin Improves Memory Impairment in Alzheimer's Disease Model Mice (5xFAD) and Attenuates Amyloid β-induced Neurite Atrophy

被引：147

作者：

Urano, Takuya ^{[1
,2
]}

Tohda, Chihiro ^{[1
]}

机构：

[1] Toyama Univ, Div Biofunct Evaluat, Res Ctr Ethnomed, Inst Nat Med, Toyama 9300194, Japan

[2] Toyama Univ, Inst Nat Med, Div Pathogen Biochem, Toyama 9300194, Japan

来源：

PHYTOTHERAPY RESEARCH | 2010年 / 24卷 / 11期

关键词：

icariin; Epimedii Herba; Alzheimer's disease; neurite atrophy; 5xFAD; spatial memory; PROTOPANAXADIOL-TYPE SAPONINS; EMBRYONIC STEM-CELLS; NEURON LOSS; TRANSGENIC MICE; MOUSE MODELS; NEURODEGENERATION; ACCUMULATION; MUTATIONS; PLAQUES; PROTEIN;

D O I：

10.1002/ptr.3183

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Essential therapeutic drugs for Alzheimer's disease (AD) have not been developed. Since the neuritic atrophy leading to synaptic losses is one of the critical causes of memory impairment in AD, the effects of several constituents in tonic herbal medicines on neuritic atrophy and memory deficits have been studied. The present study investigated the effects of icariin, a main constituent in Epimedii Herba, a well known tonic crude drug, in an in vitro AD model and transgenic mouse AD model (5xFAD). Amyloid beta(1-42)-induced atrophies of axons and dendrites were restored by post-treatment with icariin in rat cortical neurons. Administration of icariin for 8 days (p.o.) improved spatial memory impairment in 5xFAD mice. These novel findings suggest that icariin may improve memory dysfunction in AD and have a potential to extend neurites even when amyloid beta-induced neurite atrophy has already occurred. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：1658 / 1663

页数：6

共 36 条

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