Summary of Group 8: Development and extension of linkage methods

被引：6

作者：

Wijsman, EM

机构：

[1] Univ Washington, Dept Med, Div Med Genet, Seattle, WA 98195 USA

[2] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[3] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA

来源：

GENETIC EPIDEMIOLOGY | 2003年 / 25卷

关键词：

bayesian; linkage analysis; multiple testing; heterogeneity; markov chain mnte carlo; genetic models;

D O I：

10.1002/gepi.10286

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The diverse contributions to Group 8 focus on the development and extension of linkage methods, and share themes that are organized around approaches to analysis. The themes discussed include issues of the accuracy of estimates of marker identity-by-descent (IBD) information, the influence of such IBD information on linkage detection, and methods for dealing with genetic heterogeneity and multiple testing. In addition, challenges were identified and solutions were offered for coping with some of the common problems of complex trait analysis, including trait model selection and computational compromises. Analytic approaches based on Bayesian and Monte Carlo methods were prominent, and provided optimistic results. (C) 2003 Wiley-Liss, Inc.

引用

页码：S64 / S71

页数：8

共 22 条

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