Modulation of Rho GTPases by type III secretion system translocated effectors of Yersinia

被引：19

作者：

Aepfelbacher, M ^{[1
]}

机构：

[1] Max Von Pettenkofer Inst Hyg & Med Microbiol, D-80336 Munich, Germany

来源：

REVIEWS OF PHYSIOLOGY, BIOCHEMICAL AND PHARMACOLOGY, VOL 152 | 2005年 / 152卷

关键词：

D O I：

10.1007/s10254-004-0035-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pathogenic species of the bacterial genus Yersinia subdue the immune system to proliferate and spread within the host organism. For this purpose yersiniae employ a type III secretion apparatus which governs injection of six effector proteins (Yersinia outer proteins; Yops) into host cells. Yops control various regulatory and signalling proteins in a unique and highly specific manner. YopE, YopT, and YpkA/YopO modulate the activity of Rho GTP-binding proteins, whereas YopH dephosphorylates phospho-tyrosine residues in focal adhesion proteins. Furthermore, YopP/YopJ and YopM affect cell survival/apoptosis and cell proliferation, respectively. In this review the focus will be on the biochemistry and cellular effects of YopT, YopE, YopO/YpkA, and YopH.

引用

页码：65 / 77

页数：13

共 66 条

[1] Characterization of YopT effects on Rho GTPases in Yersinia enterocolitica-infected cells [J].

Aepfelbacher, M ;

Trasak, C ;

Wilharm, G ;

Wiedemann, A ;

Trülzsch, K ;

Krauss, K ;

Gierschik, P ;

Heesemann, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (35) :33217-33223

[2] Modulation of Rho GTPases and the actin cytoskeleton by Yersinia outer proteins (Yops) [J].

Aepfelbacher, M ;

Heesemann, J .

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2001, 291 (04) :269-276

[3] In vitro GAP activity towards RhoA, Rac1 and Cdc42 is not a prerequisite for YopE induced HeLa cell cytotoxicity [J].

Aili, M ;

Telepnev, M ;

Hallberg, B ;

Wolf-Watz, H ;

Rosqvist, R .

MICROBIAL PATHOGENESIS, 2003, 34 (06) :297-308

[4] Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH [J].

Alonso, A ;

Bottini, N ;

Bruckner, S ;

Rahmouni, S ;

Williams, S ;

Schoenberger, SP ;

Mustelin, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (06) :4922-4928

[5] Efficient uptake of Yersinia pseudotuberculosis via integrin receptors involves a Rac1-Arp 2/3 pathway that bypasses N-WASP function [J].

Alrutz, MA ;

Srivastava, A ;

Wong, KW ;

D'Souza-Schorey, C ;

Tang, M ;

Ch'ng, LE ;

Snapper, SB ;

Isberg, RR .

MOLECULAR MICROBIOLOGY, 2001, 42 (03) :689-703

[6] YopE of Yersinia, a GAP for Rho GTPases, selectively modulates Rac-dependent actin structures in endothelial cells [J].

Andor, A ;

Trülzsch, K ;

Essler, M ;

Roggenkamp, A ;

Wiedemann, A ;

Heesemann, J ;

Aepfelbacher, M .

CELLULAR MICROBIOLOGY, 2001, 3 (05) :301-310

[7] Toll-like receptor 2-mediated NF-κB activation requires a RacI-dependent pathway [J].

Arbibe, L ;

Mira, JP ;

Teusch, N ;

Kline, L ;

Guha, M ;

Mackman, N ;

Godowski, PJ ;

Ulevitch, RJ ;

Knaus, UG .

NATURE IMMUNOLOGY, 2000, 1 (06) :533-540

[8] The Yersinia Ser/Thr protein kinase YpkA/YopO directly interacts with the small GTPases RhoA and Rac-1 [J].

Barz, C ;

Abahji, TN ;

Trülzsch, K ;

Heesemann, J .

FEBS LETTERS, 2000, 482 (1-2) :139-143

[9] Rho GTPases and their effector proteins [J].

Bishop, AL ;

Hall, A .

BIOCHEMICAL JOURNAL, 2000, 348 (02) :241-255

[10] The RhoGAP activity of the Yersinia pseudotuberculosis cytotoxin YopE is required for antiphagocytic function and virulence [J].

Black, DS ;

Bliska, JB .

MOLECULAR MICROBIOLOGY, 2000, 37 (03) :515-527

← 1 2 3 4 5 6 7 →