Modulation of Rho GTPases by type III secretion system translocated effectors of Yersinia

被引：19

作者：

Aepfelbacher, M ^{[1
]}

机构：

[1] Max Von Pettenkofer Inst Hyg & Med Microbiol, D-80336 Munich, Germany

来源：

REVIEWS OF PHYSIOLOGY, BIOCHEMICAL AND PHARMACOLOGY, VOL 152 | 2005年 / 152卷

关键词：

D O I：

10.1007/s10254-004-0035-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pathogenic species of the bacterial genus Yersinia subdue the immune system to proliferate and spread within the host organism. For this purpose yersiniae employ a type III secretion apparatus which governs injection of six effector proteins (Yersinia outer proteins; Yops) into host cells. Yops control various regulatory and signalling proteins in a unique and highly specific manner. YopE, YopT, and YpkA/YopO modulate the activity of Rho GTP-binding proteins, whereas YopH dephosphorylates phospho-tyrosine residues in focal adhesion proteins. Furthermore, YopP/YopJ and YopM affect cell survival/apoptosis and cell proliferation, respectively. In this review the focus will be on the biochemistry and cellular effects of YopT, YopE, YopO/YpkA, and YopH.

引用

页码：65 / 77

页数：13

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