Hydroxynitrile lyases in stereoselective catalysis

被引：77

作者：

Effenberger, F

Förster, S

Wajant, H

机构：

[1] Univ Stuttgart, Inst Organ Chem, D-70569 Stuttgart, Germany

[2] Univ Stuttgart, Inst Zellbiol & Immunol, D-70569 Stuttgart, Germany

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2000年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0958-1669(00)00141-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

(R)- as well as (S)-cyanohydrins are now easily available as a result of the excellent accessibility, the relatively high stability and the easy handling of hydroxynitrile lyases (HN Ls). The optimization of reaction conditions (solvent, temperature, and using site-directed mutagenesis, etc.) has enabled HNL-catalyzed preparations of optically active cyanohydrins on a technical scale. The enantioselectivity of chiral metal-complex-catalyzed additions of trimethylsilyl cyanide to aldehydes has been improved, but is, by far, not yet competitive with the HNL-catalyzed reactions.

引用

收藏

页码：532 / 539

页数：8

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