Alpha interferon administration during structured interruptions of combination antiretroviral therapy in patients with chronic HIV-1 infection: INTERVAC ANRS 105 trial

被引：29

作者：

Boue, Francois ^{[1
]}

Reynes, Jacques ^{[2
]}

Rouzioux, Christine ^{[3
]}

Emilie, Dominique ^{[4
,5
]}

Souala, Faouzi ^{[6
]}

Tubiana, Rolland ^{[7
]}

Goujard, Cecile ^{[8
]}

Lancar, Remi ^{[9
]}

Costagliola, Dominique ^{[8
,9
]}

机构：

[1] Univ Paris Sud, Hop Antoine Beclere, APHP, Serv Med Interne & Immunol Clin, Clamart, France

[2] Hop Gui de Chauliac Malad Infect & Trop, Montpellier, France

[3] Univ Paris 05, Hop Necker Enfants Malad, APHP, Virol Lab,EA 3620, Paris, France

[4] Univ Paris Sud, INSERM, U764, Clamart, France

[5] Hop Antoine Beclere, Serv Microbiol Immunol Biol, Clamart, France

[6] CHU Pontchaillou, Serv Malad Infect Reanimat Med, Rennes, France

[7] Hop La Pitie Salpetriere, APHP, Serv Malad Infect & Trop, Paris, France

[8] Univ Paris Sud, Hop Bicetre, APHP, Serv Med Interne, F-94275 Le Kremlin Bicetre, France

[9] INSERM U943, Paris, France

来源：

AIDS | 2011年 / 25卷 / 01期

关键词：

CD8; T-CELLS; TYPE-1; INTERFERONS; CLONAL EXPANSION; PROMOTE; RNA; DIFFERENTIATION;

D O I：

10.1097/QAD.0b013e328340a1e7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interferon-alpha administration during structured treatment interruptions (STIs) was studied in a phase III trial. We randomized 168 chronically infected HIV undetectable under combined antiretroviral therapy patients to have three STIs with or without a-interferon. The number of patients who had to resume treatment during post-STI follow-up was not significantly different between the two arms. Patients with a low CD4 nadir and a high baseline HIV-DNA had a higher risk of treatment resumption in the interferon arm.

引用

页码：115 / 118

页数：4

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