E2F and signal transduction pathways

被引:11
作者
Chaussepied, M [1 ]
Ginsberg, D [1 ]
机构
[1] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel
基金
以色列科学基金会;
关键词
E2F; signal transduction; PI3-K/AKT;
D O I
10.4161/cc.4.3.1556
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The E2F family of transcription factors is most well known for its ability to regulate the expression of genes required for DNA replication and cell cycle progression. However, recent studies indicate that E2F can also regulate transcription of upstream components of signal transduction pathways. Here we discuss the effects of E2F activity on signal transduction pathways and its potential biological consequences.
引用
收藏
页码:392 / 396
页数:5
相关论文
共 27 条
[1]   COEXPRESSION OF A PDGF-LIKE GROWTH-FACTOR AND PDGF RECEPTORS IN A HUMAN OSTEO-SARCOMA CELL-LINE - IMPLICATIONS FOR AUTOCRINE RECEPTOR ACTIVATION [J].
BETSHOLTZ, C ;
WESTERMARK, B ;
EK, B ;
HELDIN, CH .
CELL, 1984, 39 (03) :447-457
[2]   E2F target genes: unraveling the biology [J].
Bracken, AP ;
Ciro, M ;
Cocito, A ;
Helin, K .
TRENDS IN BIOCHEMICAL SCIENCES, 2004, 29 (08) :409-417
[3]   Transcriptional regulation of AKT activation by E2F [J].
Chaussepied, M ;
Ginsberg, D .
MOLECULAR CELL, 2004, 16 (05) :831-837
[4]   E2F-1 is essential for normal epidermal wound repair [J].
D'Souza, SJA ;
Vespa, A ;
Murkherjee, S ;
Maher, A ;
Pajak, A ;
Dagnino, L .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (12) :10626-10632
[5]   The genetics of the E2F family of transcription factors: shared functions and unique roles [J].
DeGregori, J .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2002, 1602 (02) :131-150
[6]   DAVID: Database for annotation, visualization, and integrated discovery [J].
Dennis, G ;
Sherman, BT ;
Hosack, DA ;
Yang, J ;
Gao, W ;
Lane, HC ;
Lempicki, RA .
GENOME BIOLOGY, 2003, 4 (09)
[7]  
GIANGRANDE PH, 2004, GENE DEV, V18
[8]   The hallmarks of cancer [J].
Hanahan, D ;
Weinberg, RA .
CELL, 2000, 100 (01) :57-70
[9]   Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis [J].
Ishida, S ;
Huang, E ;
Zuzan, H ;
Spang, R ;
Leone, G ;
West, M ;
Nevins, JR .
MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (14) :4684-4699
[10]   Growth factor-dependent signaling and cell cycle progression [J].
Jones, SM ;
Kazlauskas, A .
FEBS LETTERS, 2001, 490 (03) :110-116