Understanding differences in predictions of HPV vaccine effectiveness: A comparative model-based analysis

被引：74

作者：

Van de Velde, Nicolas ^{[1
,2
]}

Brisson, Marc ^{[1
,4
]}

Boily, Marie-Claude ^{[1
,3
]}

机构：

[1] Univ Laval, Dept Med Sociale & Prevent, Quebec City, PQ, Canada

[2] Ctr Hosp Univ Quebec, Unite Rech St Publ & St Environm, Quebec City, PQ, Canada

[3] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, London, England

[4] Hop St Sacrement, CHA Univ Quebec, URESP, Ctr Rech FRSQ, Quebec City, PQ G1S 4L8, Canada

来源：

VACCINE | 2010年 / 28卷 / 33期

关键词：

Human papillomavirus; Vaccines; Dynamic transmission model; HUMAN-PAPILLOMAVIRUS VACCINATION; COST-EFFECTIVENESS ANALYSIS; POPULATION-LEVEL IMPACT; CERVICAL-CANCER; NATURAL-HISTORY; ECONOMIC-EVALUATION; TRANSMISSION DYNAMICS; INFECTION; TYPE-16; RISK;

D O I：

10.1016/j.vaccine.2010.05.056

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mathematical models of HPV vaccine effectiveness and cost-effectiveness have produced conflicting results. The aim of this study was to use mathematical models to compare and isolate the impact of the assumptions most commonly made when modeling the effectiveness of HPV vaccines. Our results clearly show that differences in how we model natural immunity, herd immunity, partnership duration. HPV types, and waning of vaccine protection lead to important differences in the predicted effectiveness of HPV vaccines These results are important and useful to assist modelers/health economists in choosing the appropriate level of complexity to include in their models, provide epidemiologists with insight on key data necessary to increase the robustness of model predictions, and help decision makers better understand the reasons underlying conflicting results from HPV models. (C) 2010 Elsevier Ltd All rights reserved.

引用

页码：5473 / 5484

页数：12

共 60 条

[1] Selected class I and class IIHLA alleles and haplotypes and risk of high-grade cervical intraepithelial neoplasia [J].