Differences in the N termini of herpes simplex virus type 1 and 2 gDs that influence functional interactions with the human entry receptor nectin-2 and an entry receptor expressed in Chinese hamster ovary cells

被引:22
作者
Zago, A [1 ]
Spear, PG [1 ]
机构
[1] Northwestern Univ, Feinberg Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA
关键词
D O I
10.1128/JVI.77.17.9695-9699.2003
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Amino acid differences at seven positions in the N termini of the glycoproteins D (gDs) specified by herpes simplex virus type 1 (HSV-1) and HSV-2 are largely responsible for the significantly higher cell fusion activity of HSV-2 gD with Chinese hamster ovary cells expressing human nectin-2 or only an endogenous hamster receptor.
引用
收藏
页码:9695 / 9699
页数:5
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