Rho GTPases: functions and association with cancer

被引：217

作者：

Ellenbroek, Saskia I. J. ^{[1
]}

Collard, John G. ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Cell Biol, NL-1066 CX Amsterdam, Netherlands

来源：

CLINICAL & EXPERIMENTAL METASTASIS | 2007年 / 24卷 / 08期

关键词：

Rho GTPases; Rac; Tiam1; signalling; cell migration; cell invasion; cancer; metastasis; tumour progression;

D O I：

10.1007/s10585-007-9119-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Rho GTPases are small proteins that act as binary molecular switches in a wide range of signalling pathways upon stimulation of cell surface receptors. Three different classes of regulatory proteins control their activity. In the activated state small GTPases are able to bind a variety of effector proteins and initiate downstream signalling. Rho GTPases regulate important cellular processes ranging from cytoskeletal remodelling and gene expression to cell proliferation and membrane trafficking. Therefore it is not surprising that deregulated Rho signalling can contribute to disturbed cellular phenotypes in a wide range of diseases. The main focus of this review will be the diversity of functions of Rho GTPases and the effects of aberrant Rho GTPase signalling in various aspects of cancer.

引用

页码：657 / 672

页数：16

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