Human cis natural antisense transcripts initiated by transposable elements

被引：84

作者：

Conley, Andrew B. ^{[1
]}

Miller, Wolfgang J. ^{[2
]}

Jordan, I. King ^{[1
]}

机构：

[1] Georgia Inst Technol, Sch Biol, Atlanta, GA 30306 USA

[2] Med Univ Vienna, Ctr Anat & Cell Biol, Labs Genome Dynam, Vienna, Austria

来源：

TRENDS IN GENETICS | 2008年 / 24卷 / 02期

关键词：

D O I：

10.1016/j.tig.2007.11.008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The capacity of human transposable elements (TEs) to promote cis natural antisense transcripts (cis-NATs) is revealed by the discovery of 48 718 human gene antisense transcriptional start sites (TSSs) within TE sequences. TSSs that yield cis-NATs are overrepresented among TE sequences, and TE-initiated cis-NATs are more abundant close to the 3' ends of genes. The TE sequences that promote antisense transcription within human genes are relatively ancient, suggesting that selection has acted to conserve their function.

引用

页码：53 / 56

页数：4

共 25 条

[1]

Brennecke J, 2007, CELL, V128, P1089, DOI 10.1016/j.cell.2007.01.043

[2] Mobile elements inserted in the distant past have taken on important functions [J].

Britten, RJ .

GENE, 1997, 205 (1-2) :177-182

[3] DNA sequence insertion and evolutionary variation in gene regulation [J].

Britten, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) :9374-9377

[4] Genome-wide analysis of mammalian promoter architecture and evolution [J].

Carninci, Piero ;

Sandelin, Albin ;

Lenhard, Boris ;

Katayama, Shintaro ;

Shimokawa, Kazuro ;

Ponjavic, Jasmina ;

Semple, Colin A. M. ;

Taylor, Martin S. ;

Engström, Par G. ;

Frith, Martin C. ;

Forrest, Alistair R. R. ;

Alkema, Wynand B. ;

Tan, Sin Lam ;

Plessy, Charles ;

Kodzius, Rimantas ;

Ravasi, Timothy ;

Kasukawa, Takeya ;

Fukuda, Shiro ;

Kanamori-Katayama, Mutsumi ;

Kitazume, Yayoi ;

Kawaji, Hideya ;

Kai, Chikatoshi ;

Nakamura, Mari ;

Konno, Hideaki ;

Nakano, Kenji ;

Mottagui-Tabar, Salim ;

Arner, Peter ;

Chesi, Alessandra ;

Gustincich, Stefano ;

Persichetti, Francesca ;

Suzuki, Harukazu ;

Grimmond, Sean M. ;

Wells, Christine A. ;

Orlando, Valerio ;

Wahlestedt, Claes ;

Liu, Edison T. ;

Harbers, Matthias ;

Kawai, Jun ;

Bajic, Vladimir B. ;

Hume, David A. ;

Hayashizaki, Yoshihide .

NATURE GENETICS, 2006, 38 (06) :626-635

[5] Over 20% of human transcripts might form sense-antisense pairs [J].

Chen, JJ ;

Sun, M ;

Kent, WJ ;

Huang, XQ ;

Xie, HQ ;

Wang, WQ ;

Zhou, GL ;

Shi, RZ ;

Rowley, JD .

NUCLEIC ACIDS RESEARCH, 2004, 32 (16) :4812-4820

[6] RNA-triggered gene silencing [J].

Fire, A .

TRENDS IN GENETICS, 1999, 15 (09) :358-363

[7] Origin of a substantial fraction of human regulatory sequences from transposable elements [J].

Jordan, IK ;

Rogozin, IB ;

Glazko, GV ;

Koonin, EV .

TRENDS IN GENETICS, 2003, 19 (02) :68-72

[8] The UCSC Genome Browser Database [J].

Karolchik, D ;

Baertsch, R ;

Diekhans, M ;

Furey, TS ;

Hinrichs, A ;

Lu, YT ;

Roskin, KM ;

Schwartz, M ;

Sugnet, CW ;

Thomas, DJ ;

Weber, RJ ;

Haussler, D ;

Kent, WJ .

NUCLEIC ACIDS RESEARCH, 2003, 31 (01) :51-54

[9] Initial sequencing and analysis of the human genome [J].

Lander, ES ;

Int Human Genome Sequencing Consortium ;

Linton, LM ;

Birren, B ;

Nusbaum, C ;

Zody, MC ;

Baldwin, J ;

Devon, K ;

Dewar, K ;

Doyle, M ;

FitzHugh, W ;

Funke, R ;

Gage, D ;

Harris, K ;

Heaford, A ;

Howland, J ;

Kann, L ;

Lehoczky, J ;

LeVine, R ;

McEwan, P ;

McKernan, K ;

Meldrim, J ;

Mesirov, JP ;

Miranda, C ;

Morris, W ;

Naylor, J ;

Raymond, C ;

Rosetti, M ;

Santos, R ;

Sheridan, A ;

Sougnez, C ;

Stange-Thomann, N ;

Stojanovic, N ;

Subramanian, A ;

Wyman, D ;

Rogers, J ;

Sulston, J ;

Ainscough, R ;

Beck, S ;

Bentley, D ;

Burton, J ;

Clee, C ;

Carter, N ;

Coulson, A ;

Deadman, R ;

Deloukas, P ;

Dunham, A ;

Dunham, I ;

Durbin, R ;

French, L .

NATURE, 2001, 409 (6822) :860-921

[10] Antisense transcripts in the human genome [J].

Lehner, B ;

Willams, G ;

Campbell, RD ;

Sanderson, CM .

TRENDS IN GENETICS, 2002, 18 (02) :63-65

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